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Spotlight on Emerging Agents for Myeloproliferative Neoplasms

Spotlight on Emerging Agents for Myeloproliferative Neoplasms. Myeloproliferative Neoplasms (MPNs). Main Goal in PV Therapy: Control Thrombotic Events. Management of High-Risk PV. ET -- Current Therapy. MF – Current Treatment. Unmet Needs in MPNs. Novel Agents in Development.

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Spotlight on Emerging Agents for Myeloproliferative Neoplasms

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  1. Spotlight on Emerging Agents for Myeloproliferative Neoplasms

  2. Myeloproliferative Neoplasms (MPNs)

  3. Main Goal in PV Therapy: Control Thrombotic Events

  4. Management of High-Risk PV

  5. ET -- Current Therapy

  6. MF – Current Treatment

  7. Unmet Needs in MPNs

  8. Novel Agents in Development

  9. JAKARTA: Fedratinib (SAR302503) Phase 3 Study in Intermediate-2 or High-Risk MF

  10. JAKARTA: Spleen Volume Response, Primary Endpoint, Primary and Secondary Analyses, ITT

  11. JAKARTA-2: Single-Arm, Multicenter, Open-Label Study (NCT01523171)[a]

  12. JAKARTA-2 Results

  13. Toxicity of Fedratinib in JAKARTA-1 and JAKARTA-2

  14. Re-Assessment of JAKARTA-2[a]

  15. Momelotinib

  16. Pacritinib: PERSIST-1 and PERSIST-2 Design

  17. Pacritinib Splenic Volume Responses

  18. PERSIST-2 Overall Survival

  19. Patient Case #1

  20. Proposed Positioning of JAK Inhibitors in Myelofibrosis

  21. Emerging Combination With JAK Inhibitors

  22. Patient Case #2

  23. Patient Case #2 (cont)

  24. Treatment Options After Failure of Ruxolitinib

  25. Imetelstat: Phase 2 Study in MF

  26. Patient Case #3

  27. Using Interferon-Alpha for PV

  28. Novel Therapies for PV

  29. Ropeginterferon vs Hydroxyurea: Findings From CONTI-PV

  30. Shifting Goals of MF Therapy With Activin Ligand Traps

  31. Sotatercept for Anemia in MF: Phase II Results

  32. Other Investigational Agents in MPN Therapy

  33. Abbreviations

  34. Abbreviations (cont)

  35. Abbreviations (cont)

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