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Trichuriasis

By Ryan Johnson. Trichuriasis. General Overview. NTD >20% of human population infected Locally underestimated Public health crucial. Trichuris Nematodes Coevolved with Man. Infects old and new world monkeys Discovered in 1740. Morphology. Fecal-Oral Transmission. Soil to mouth.

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Trichuriasis

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  1. By Ryan Johnson Trichuriasis

  2. General Overview • NTD • >20% of human population infected • Locally underestimated • Public health crucial

  3. Trichuris Nematodes Coevolved with Man • Infects old and new world monkeys • Discovered in 1740

  4. Morphology

  5. Fecal-Oral Transmission • Soil to mouth

  6. Embryonic Development Must Occur Outside of the Human I won’t be able to hatch in your stomach if you eat me now. Gimme 3 weeks! Time’s up… …EAT ME!!! 3 weeks later

  7. Signs and Symptoms • Light infestation – asymptomatic • Severe infestation – GI problems

  8. Treatment • Mebendazole

  9. Prevents Microtubule Polymerization

  10. Preventive Chemotherapy • Heaviest burden on kids • Treatment 2x a year • 1 dose = fraction USD

  11. http://en.wikipedia.org/wiki/Trichuriasis • Fernando, RanjanL; Tropical infectious diseases : epidemiology, investigation, diagnosis and management; London : Greenwich Medical Media, 2004. • http://www.who.int/intestinal_worms/en/index.html • Hutchinson, et al; Clinical Trial of Mebendazole, A Broad-spectrum Anthelminthic; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1681918/pdf/brmedj01446-0019.pdf/?tool=pmcentrez • Miller, et al; Mebendazole, An Effective Anthelminticfor Trichuriasisand Enterobiasis; http://jama.ama-assn.org/cgi/reprint/230/10/1412.pdf

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