The mechanism of HCV extrahepatic infection. Michael M.C. Lai Institute of Molecular Biology Academia Sinica. Sept. 21, 2012 at Wuhan. Clinical manifestations of HCV. Evidence that PBMC infection by HCV is causally linked to B cell lymphoma.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Michael M.C. Lai
Institute of Molecular Biology
Sept. 21, 2012 at Wuhan
Hecker, E. & Ott, M. 2011. Ubique ties between hepatitis C virus replication and intracellular lipids. Cell. 22(6).243
Molecular mechanism of viral lympho- vs hepatotropism virus replication and intracellular lipids.
T7 in vitro
into Huh7.5 and Raji
SB virus RNA, but not JFH-1 Virus, Replicates in Raji Cells virus replication and intracellular lipids.
Chimera Virus containing E1-E2 of SB Strain Produces CellsHigh Levels of HCV RNA in Raji Cells
Infection of Cellstarget cells
GFP orluciferase expression
Study virus entry, receptors, host range, etc.
HCV Pseudoparticle System (HCVpp)
A retrovirus reporter virus with HCV envelope proteins
GFP or Luciferase
by E1-E2 of SB Strain in Raji Cells
FACS for GFP reporter with HCVpp at 72 h p.i
Normalized for p24 HIV core antigen
Mutation frequencies of p53 and VH
in HCV-infected human B cell lines