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The Immune and Enteric Systems. Sue Howell, DVM. The Immune System. Identify potentially injurious substances Distinguish self from non-self Assess level of threat Mount an appropriate response Repair damage. www.nobelprize.org. Inflammation . Body’s natural response to insult

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the immune system
The Immune System
  • Identify potentially injurious substances
  • Distinguish self from non-self
  • Assess level of threat
  • Mount an appropriate response
  • Repair damage

www.nobelprize.org

slide3

Inflammation

  • Body’s natural response to insult
  • Vital to survival
  • Meant to be turned on for a short time
ingredients t hat s upport the immune s ystem
Ingredients that support the immune system
  • Spanish black radish
  • RNA
  • Buckwheat leaf juice and seed
  • L-glutamine
  • http://vimeo.com/62369403
adaptogens
Adaptogens

Ashwaganda

Ginseng

(Withaniasomnifera)

(Eleutherococcussenticosus)

canine immune support feline immune support
Canine Immune SupportFeline Immune Support
  • Indications
  • General immune system support
  • Colder climates or during the fall/winter months
  • When kenneled or in a shelter
slide10
Star

History

Presentation

  • 6 year old F/S DSH
  • Chronic URI resolved with doxycycline, hyperglobulinemia with polyclonal gammopathy diagnosed 1 year prior
    • No follow up viral panel. No viral testing
  • Severe crusting and ulceration of the ears, face, and forelimbs
  • Lesions bleed easily when touched
  • Splenomegaly
  • Lethargy
slide11
Star

Diagnostics

Recommendation

  • Negative skin scraping, 3+ cocci on skin cytology, woods light negative
  • FIV positive
  • Hyperglobulinemia
  • Lymphopenia
  • Clavamox
  • Itraconazole pending fungal culture
  • Nutritional support for the immune system
  • Grain-free canned diet
slide12
Star

Recheck (2 weeks)

Recommendation

  • Lesions were drying up and 50% resolved
  • More active
  • Fungal culture negative
  • Continue Clavamox
  • Continue nutritional support for the immune system
slide13
Star

Recheck (4 weeks)

Recommendation

Recheck (6 weeks)

  • Skin lesions resolved
  • Spleen smaller and less nodular upon palpation
  • Continue nutritional support for the immune system
  • No lesions
  • Active and glossy hair coat
  • Spleen unchanged
  • Owner is thrilled!
the g astrointestinal system
The Gastrointestinal System
  • 70% of immune system
  • Enterocytes
  • Mucosal barrier
  • Gut flora
  • Enteric nervous system
leaky gut syndrome
Leaky Gut Syndrome

Source: www.ktcolgan.com

gut flora
Gut Flora
  • detoxifies some xenobiotics
  • maintains the intraluminal environment
  • dialogues with the immune tissues of the gut
  • stimulates bone marrow

Biomedical Imaging Unit, Southampton General Hospital

canine enteric support feline enteric support
Canine Enteric SupportFeline Enteric Support

Systems Supported

  • Digestive system
  • Liver
  • Kidneys
  • Immune system
  • Endocrine system
canine enteric support feline enteric support1
Canine Enteric SupportFeline Enteric Support

Indications

  • General enteric support
  • Patients with increased metabolic demand
  • Hepatic patients in need of additional enteric support as indicated by ALT, alkaline phosphatase, bile acids studies, and enteric histopathology
  • Patients with immune challenges
slide21
Lexi
  • History
  • Pancreatitis 2 years ago
  • “Sensitive stomach” and infrequent soft stool
  • 11/27/13 – diarrhea and one episode of vomiting, suspected URI
  • 12/3/13 – suspected pneumonia
  • 12/31/13 – OSU consult
  • 1/1/14 – whipworms diagnosed
slide22
Lexi

Diagnosis

Lymphangectasia with concomminent mild IBD

slide23
Lexi
  • Medications
  • Azothioprine, Tylan powder, low dose aspirin, Prednisone, Vit B12
  • Nutritional support for
  • the immune system
  • the gastrointestinal system
  • essential amino acids
  • Progress
  • 2/4/14 normal protein levels, weaning off medications, continue nutritional support