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Melatonin Treatment Effects on Vessel Contractility under Hypoxic and Normoxic Conditions

This study examines the impact of melatonin treatment on vessel contractility in different conditions using small arteries with or without fat. The results show significant improvements in vessels without fat in certain conditions, while the effects vary with the presence of fat.

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Melatonin Treatment Effects on Vessel Contractility under Hypoxic and Normoxic Conditions

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  1. ONLINE MATERIAL The improvement after treatment with melatonin was also seen in vessels from CLM without fat (NoF) during hypoxia (ANOVA p<0.05), while in NoF ob/ob the improvement was not statistically significant (Figure 1). In CLM, but not in ob/ob, melatonin decreased contractile responses also in NoF vessels pre-incubated with iberiotoxin (ANOVA p<0.05) (Figure 2).When with fat (WF) vessels were examined, after preincubation with iberiotoxin, vessels from ob/ob treated with melatonin show a reduction of the contractile responses (ANOVA p= 0.036), while in CLM the difference was not statistically significant (p=0.25) (Figure 3). Melatonin treatment did not affect WF vessels from either CLM or ob/ob kept in normoxic conditions (Figure 4).

  2. Figure 1 % of KPSS constriction [NA] (Mol/L) Contractility of small arteries without fat (noF) from CLM and ob/ob kept in hypoxic conditions: effect of treatment with melatonin (MEL). CLM: ANOVA p<0.05 hypoxia vs. hypoxia+MEL; ob/ob ANOVA p=NS hypoxia vs. hypoxia+MEL. .

  3. Figure 2 % of KPSS constriction [NA] (Mol/L) Contractility of small arteries without fat (NoF) from CLM and ob/ob pre-incubated with iberiotoxin: effect of treatment with melatonin (MEL). CLM: ANOVA p<0.05 NoF+iberotoxin vs. NoF+iberotoxin+MEL; ob/ob ANOVA p=NS NoF+iberotoxin vs. NoF+iberotoxin.

  4. Figure 3 % of KPSS constriction [NA] (Mol/L) Contractility of small arteries with fat (WF) from CLM and ob/ob pre-incubated with iberiotoxin: effect of treatment with melatonin (MEL). CLM: ANOVA p=0.25 (NS) WF +iberotoxin vs. WF+iberotoxin+MEL; ob/ob: ANOVA p=0.036 WF +iberotoxin vs. WF+iberotoxin.

  5. Figure 4 % of KPSS constriction [NA] (Mol/L) Contractility of small arteries with fat (WF) from CLM and ob/ob: effect of treatment with melatonin (MEL). CLM: ANOVA p=NS WF vs. WF +MEL; ob/ob: ANOVA p=NS WF vs. WF+MEL

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