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THIS LECTURE REVIEWS

THIS LECTURE REVIEWS. RISK FOR ALCOHOLISM SENSITIVITY (LR) AS RISK GENES & ENVIRONMENT RECENT DEVELOPMENTS. THIS LECTURE REVIEWS. RISK FOR ALCOHOLISM SENSITIVITY (LR) AS RISK GENES & ENVIRONMENT RECENT DEVELOPMENTS. ALCOHOLISM RISK. Multiple Characteristics and Genes.

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THIS LECTURE REVIEWS

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  1. THIS LECTURE REVIEWS RISK FOR ALCOHOLISM SENSITIVITY (LR) AS RISK GENES & ENVIRONMENT RECENT DEVELOPMENTS

  2. THIS LECTURE REVIEWS RISK FOR ALCOHOLISM SENSITIVITY (LR) AS RISK GENES & ENVIRONMENT RECENT DEVELOPMENTS

  3. ALCOHOLISM RISK Multiple Characteristics and Genes

  4. COMPLEX GENETIC RISK • Myocardial Infarction • Type 2 Diabetes • Cancer

  5. RISK FACTORS  Alcohol Metabolizing Enzymes  Level of Response (LR)  Impulsivity  Psychiatric Disorders

  6. ALCOHOL METABOLISM Alcohol ADH Acetaldehyde ALDH CO2 + H2O

  7. THIS LECTURE REVIEWS RISK FOR ALCOHOLISM SENSITIVITY (LR) AS RISK GENES & ENVIRONMENT RECENT DEVELOPMENTS

  8. LR RATIONALE Youth Drink for Effects If Need More, Drink More Then Heavy Drinking Affects Peers Expectations Stress

  9. SRE TIME FRAME:DRINKS 1st 5 Recent Heaviest NEEDED TO: Times 3 Mos Feel Effect Feel Dizzy or Slur Speech Stumble Fall Asleep

  10. LR IS GENETIC 1° Relatives .20 Unrelated .02 Twin Heritability 60%

  11. LR PREDICTS OUTCOME  San Diego Study  Australian Twins  Danish Adoptees  Colorado Twins • COGA Kids • ALSPAC Kids • Pittsburgh Study

  12. LR IS: • Genes and Environment • Observed Early • Predicts Diagnosis

  13. THIS LECTURE REVIEWS RISK FOR ALCOHOLOISM SENSITIVITY (LR) AS RISK GENES & ENVIRONMENT RECENT DEVELOPMENTS

  14. GENES FOR LR • Animal Models • Candidates • Association

  15. CANDIDATE GENES Serotonin (5-HTT) K-Channels (KCN) GABA (GABRA6) Dopamine (DRD2/ANKK1)

  16. CANDIDATES GABRA6 COMT 5HTT GABRG2 DRD2/ANKK1 ADORA GABRA5 DRD4 NPY GABRA1 AUTS2 EGFR GABRA2 KCNMA1 DGKZ ADH4 CHRNA5 GNAS ADH1B NMDA PK ADH1C CYP2E

  17. KEY FACTORS FH EXPECT LR COPE PEER ALCOUT

  18. PEER EXPECT LR ALCOUT FHalc COPE PROJECTED

  19. THIS LECTURE REVIEWS RISK FOR ALCOHOLOISM SENSITIVITY (LR) AS RISK GENES & ENVIRONMENT RECENT : fMRI & PREVENTION

  20. 120 Subjects • 240 fMRI Sessions • 480 Sessions

  21. SAMPLE (N=120) Low LR High LR Age 19.8 20.1 % Female 52.6 52.6 Drink f/mo 4.5 3.5 Drink/Daya 4.1 3.3 # Conduct Probs 0.41 0.31 60 min BAC 0.06 0.06

  22. KEY FINDINGS • fMRI Relates to LR • Low LR and High LR Differ • Placebo • Alcohol • Interactions • Implications

  23. PREVENTION Teach About Risk Prevent Based on Risk

  24. THE STUDY • Questionnaire To Students ~70% Response Select Matched Low and High LR • Two Prevention Groups LR-Based State of the Art • Four 45-min Internet Sessions Each

  25. USUAL DRINKS ACROSS TIME

  26. PREVENTION: Develop for Specific Risk Evaluate in Subgroups

  27. THIS LECTURE REVIEWED RISK FOR ALCOHOLISM SENSITIVITY (LR) AS RISK GENES & ENVIRONMENT RECENT DEVELOPMENTS

  28. GENES AND ALCOHOLISM 4 x ↑ Risk for COAs 4 x ↑ Risk for Adopted COAs Higher Risk for ID Twins

  29. ALCOHOLISM RISK Multiple Characteristics and Genes

  30. RISK FACTORS  Alcohol Metabolizing Enzymes  Level of Response (LR)  Impulsivity  Psychiatric Disorders

  31. SRE TIME FRAME:DRINKS 1st 5 Recent Heaviest NEEDED TO: Times 3 Mos Feel Effect Feel Dizzy or Slur Speech Stumble Fall Asleep

  32. LR RATIONALE Youth Drink for Effects If Need More, Drink More Then Heavy Drinking Affects Peers Expectations Stress

  33. LR IS: • Genes and Environment • Observed Early • Predicts Dx

  34. PEER EXPECT LR ALCOUT FHalc COPE PROJECTED

  35. BRAIN MECHANISMS • Images relate to LR • Low LR differ from high LR • Placebo • Alcohol • Interactions

  36. PREVENTION Teach About Risk Prevent Based on Risk

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