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Молекула памяти

Что-то с памятью моей стало, То, что было не со мной, помню…. Молекула памяти. P.BALABAN Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences. C ellular mechanisms of learning and memory have been highly conserved during evolution. +. PKm ζ.

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Молекула памяти

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  1. Что-то с памятью моей стало, То, что было не со мной, помню… Молекула памяти P.BALABAN Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences

  2. Cellular mechanisms of learning and memory have been highly conserved during evolution +

  3. PKmζ Protein Kinase M zeta Constitutively active isoform of Protein Kinase C (PKC) Functions in the storage of memory.

  4. Protein nitrosylation Nitrosylation is a protein modification in which a nitrosyl group is post-translationally added to a protein. S-nitrosylation, discovered by Joseph Loscalzo, is an important biological reaction of nitric oxide; it refers to the conversion of thiol groups, including cysteine residues in proteins, to form S-nitrosothiols (RSNOs). S-Nitrosylation is a mechanism for dynamic, post-translational regulation of most or all major classes of protein.

  5. Known: Nitric oxide is necessary for synaptic plasticity NO in small concentrations activates protein synthesis via G-pathways, while in big concentrations LOCALLY impairs proteins functioning via S-nitrosylation mechanism. Question: ? NO is necessary both for memory formation and local memory plastification in synapses?

  6. Оксид азота необходим для модификации памяти во время реконсолидации

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