Toxic Epidermal Necrolysis. Kristine Scruggs, MD AM Report July 28, 2009. Definition. SJS/TEN: Lesions: Small blisters on dusky purpuric macules or atypical targets Mucosal involvement common Prodrome of fever and malaise common Stevens-Johnson Syndrome: Rare areas of confluence.
Kristine Scruggs, MD
July 28, 2009
SJS: age 25-47, TEN: age 46-63
Greater extent of detachment
Certain HLA types
Polymorphisms in IL4 receptor gene
Concomitant viral infections
Underlying immunologic diseases
UV light, radiation therapy
Higher doses of known offendersEpidemiology
by cytotoxic T cells and NK cells)
intracellular adhesion molecule
Subepidermal split with cell-poor bullous.
Epidermis shows full thickness necrosis.
Associated with gluten intolerance
Affects middle-aged or elderly
Mucosal involvement, sometimes cutaneous
Linear IgA Disease
Itchy, ring-shaped, no internal disease
Herpes Simplex Virus