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ORNs

Wild type. Kir Mice. ORNs. G. MC. ORNs. G. MC. Quantify the tuning curve shape by computing S (Sparseness) Index . (Michelle L Schlief & Rachel Wilson, 2007). Interval. Water Delivery. Water Port IR Cross. Two-choice Test. Initial Training

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ORNs

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  1. Wild type Kir Mice ORNs G MC ORNs G MC

  2. Quantify the tuning curve shape by computing S (Sparseness) Index. (Michelle L Schlief & Rachel Wilson, 2007)

  3. Interval Water Delivery Water Port IR Cross Two-choice Test • Initial Training • Motivation to water- Training water-deprived (about 1.5 ml per day) mice. • Mice familiar with the boxes. • Interest to holes- Mice were rewarded with water for every nose poke into the sniff port. • Training 1- Associate the odor with the water port. • a. Odor A with water A. • b. Odor B with water B. • 5. Two choice WaterA Odor WaterB 3.

  4. Methyl Butyrate Methyl Valerate E-2 E-3 E-4 E-5 E-6

  5. E-1 E-2 E-3 E-4 E-5 E-6 E-7 E-8 E-9 E-2 Wt (normal projection) mice show better performance than Het (disrupted projection) at some concentration.

  6. Cross-habitation Odor presenting sequence: MO MO MO MO MO OdorA OdorA OdorA OdorA OdorA OdorB OdorB Waiting time = 5 min, Odor presenting duration = 2 min, Interval = 3 mins Flow rate: total: 300ml/min each box, 30ml/min for odor deliver each box.

  7. Amyl Acetate Vs Heptanal B6, 12mice

  8. Methyl Butyrate vs Methyl Valerate B6, 12mice

  9. Amyl Acetate Vs Heptanal WT/HET 9 animals

  10. Amyl Acetate vs Heptanal HET/HET 9 animals

  11. Methyl Butyrate vs Methyl Valerate WT/HET 9 animals

  12. Methyl Butyrate vs Methyl Valerate HET/HET 9 animals

  13. Ultrasonic vocalization

  14. .contact with awake female

  15. Mixture Dilution Amyl Acetate vs. Heptanal

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