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School of Chemical Sciences Seminar Mass spectrometry-led catalyst discovery Scott McIndoe

School of Chemical Sciences Seminar Mass spectrometry-led catalyst discovery Scott McIndoe Department of Chemistry, University of Victoria, BC, Canada. Intermediate PdL 2 (R)(X) (100 ×). Product. Intermediate PdL 2 (R)(R’) (100 ×). Byproduct. Reactant.

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School of Chemical Sciences Seminar Mass spectrometry-led catalyst discovery Scott McIndoe

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  1. School of Chemical Sciences Seminar Mass spectrometry-led catalyst discovery Scott McIndoe Department of Chemistry, University of Victoria, BC, Canada Intermediate PdL2(R)(X)(100 ×) Product Intermediate PdL2(R)(R’)(100 ×) Byproduct Reactant Thursday, March 14, 2013, 4 pm, 407 followed by sherry hour in the 5th floor common room

  2. Abstract Determination of catalytic mechanisms is a challenging task, not least because intermediates are difficult to observe due to their relatively low concentration. Electrospray ionization mass spectrometry has some distinct advantages in this regard: it is fast, highly sensitive and has a wide dynamic range, allowing the simultaneously monitoring of the concentration of starting materials, products, byproducts and intermediates. However, the technique has numerous weaknesses that must be overcome through the application of appropriate methodology. Our approach will be described in the context of our investigations into palladium-catalyzed cross-coupling reactions, including the copper-free Sonogashira and Suzuki reactions. CV Scott McIndoe was born in Rotorua and raised on a farm in the Mamaku ranges. He completed his DPhil in synthetic organometallic chemistry at the University of Waikato under the supervision of Professor Brian Nicholson. In 1998, he took up a New Zealand Foundation for Research, Science & Technology (FRST) Postdoctoral Fellowship at the University of Cambridge, UK, where he worked in the group of Professor Brian Johnson FRS. In 2000, he began a college lectureship, teaching at Trinity and Newnham Colleges, Cambridge, and continued his research in the Department of Chemistry. Three years later he moved to his current position in the chemistry department at UVic, and was promoted to associate professor in 2009. The McIndoe group have particular interests in the areas of organometallic catalysis and synthesis, and develop and use novel mass spectrometric techniques to enable rapid catalyst discovery, mechanism elucidation and reaction optimisation.

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