INTRODUCTION. Depression afflicts approximately 5% of the population, 1-2% with bipolar disorder. Suicide from depression is 25-30% of depressed population. Depression 2-3 X higher in women. 70% of patients have response to drugs. There is major depression and secondary mood disorders.
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Increased production of inositol phosphate (IP-3) which increases intracellular Ca2+ signalling
Increased DAG which:
activates PKC which phosphorylates a number of substrates including myristoylated alanine rich C kinase (MARCK)
MARCK activates nuclear transcription factors and modulates genes that increase neuromodulatory peptide hormones and alters cell signalling which:
changes neurotransmitter synthesis
neuronal cell loss (prefrontal cortex?)