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MACULAR DEGENERATION: CLINICAL ANALYTICAL STUDY Dr. C. SRINIVAS, M.D

MACULAR DEGENERATION: CLINICAL ANALYTICAL STUDY Dr. C. SRINIVAS, M.D NIZAMIA GENERAL HOSPITAL, PVRI HYDERABAD INDIA NO FINANCIAL AID TO THIS STUDY. AGE RELATED MACULAR DEGENERATION IS THE LEADING CAUSE OF BLINDNESS IN THE WORLD [AREDS REPORT-2001]. 45% VISUAL DISABILITY IN THE USA

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MACULAR DEGENERATION: CLINICAL ANALYTICAL STUDY Dr. C. SRINIVAS, M.D

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  1. MACULAR DEGENERATION: CLINICAL ANALYTICAL STUDY Dr. C. SRINIVAS, M.D NIZAMIA GENERAL HOSPITAL, PVRI HYDERABAD INDIA NO FINANCIAL AID TO THIS STUDY

  2. AGE RELATED MACULAR DEGENERATION IS THE LEADING CAUSE OF BLINDNESS IN THE WORLD [AREDS REPORT-2001]

  3. 45% VISUAL DISABILITY IN THE USA DUE TO ARMD [KLEIN et al –1992] 10 MILLION PEOPLE IN THE USA [FRIEDMAN.DS COLAMAIN.BJ 2004]

  4. PREVALANCE IS INCREASING IN GREAT BRITAN – (EIANS et al 1996) AND IN JAPAN [MARUO 1991] INCREASING RAPIDLY IN DEVELOPING COUNTRIES AND IN INDIA TOO.

  5. IS A COMPLEX MULTIFACTORIAL DISORDER (STAURT RICHER et al 2004) INVOLVES GENETIC, C.V, ENVIRONMENTAL AND NUTRITIONAL.

  6. NO PROVEN TREATMETN IS AVAILABLE, NEITHER SLOWS OR PREVENT THE PROCESS OF ARMD [AREDS REPORT-2001]

  7. INCIDENCE IS RAPIDLY INCREASING WITH AGE 9% INVOLVES ABOVE 65 Yrs 30% INVOLVES ABOVE 75 Yrs [VAN NEW KRIK 2000] 50% AFFECTS BY 2020 AD [FREDMAN.DS 2004]

  8. EDIDEMIOLOGICAL STUDIES MAY NOT BE ABLE TO FIND THE UNDERSTANDING OF THE ARMD. BUT HELPS TO ASSES THE CONTRIBUTING FACTOR TO REDUCE THE ECONOMICAL, SOCIAL, NATIONAL GLOBAL AND PERSONAL PROBLEMS

  9. MATERIAL AND METHODS 4500 MACULAR DEGENARATION CASES CLINICALLY SELECTED AND ANALYTICALLY STUDIED TO ASSES THE VARIOUS AETIO PATHOGENIC FACTOR IN NIZAMIA GENERAL HOSPITAL FOR A DECADE

  10. SEX WISE DISTRIBUTION SEX NO. OF PERCENTAGE CASES MALE 2500 55.5% FEMALE 2000 44.5%

  11. TYPES OF MACULAR DEGENERATION TYPE NO. OF PERCENTAGE CASES WET 1700 37.7% DRY 2800 62.44%

  12. AGE WISE DISTRIBUTION AGE NO. OF PERCENTAGE CASES 40-49 500 11.1% 50-59 700 15.5% 60-69 900 20% 70-79 1300 28.8% 80-89 1100 24.4%

  13. URBAN AND RURAL DISTRIBUTION GROUP NO. OF PERCENTAGE CASES URBAN 3000 66.6% RURAL 1500 32.6%

  14. OCCUPATIONAL DISTRIBUTION GROUP NO. OF PERCENTAGE CASES EXECUTIVE 2000 44.4% NONEXECUTIVE 1500 32.6% AGRICULTURE 1000 22.2%

  15. SOCIO-ECONOMICAL DISTRIBUTION GROUP NO. OF PERCENTAGE CASES HIGHER 1900 42.2% MODERATE 1600 35.5% LOW 1000 22.2%

  16. SMOKING GROUP NO. OF PERCENTAGE CASES SMOKERS 2400 53.3% NON SMOKERS 2100 46.6%

  17. ALCOHOL GROUP NO. OF PERCENTAGE CASES ALCOHOLICS 2500 55.5% NON ALCOHOLICS 2000 44.5%

  18. FOOD HABITS GROUP NO. OF PERCENTAGE CASES CARBOHYDRATES 1300 28.8% FATTY 1500 33.5% PROTEINS 1000 22.2% NUTIRTIOUS SUPPLIMENTATION 700 18.8%

  19. DIABETIC PATTERS GROUP NO. OF PERCENTAGE CASES VEGETARIAN 2000 44.5% NON VEGETARIANS 2500 55.5%

  20. YOGA / MEDITATION GROUP NO. OF PERCENTAGE CASES YOGA 2000 44.5% NON YOGA 2500 55.5%

  21. H/o OF MEDICATION GROUP NO. OF PERCENTAGE CASES STERIODS 750 16.5% ANTI BIOTICS 700 15.5% ANTI HISTAMINS 600 13.3% ANTI INFLAMATORY 650 14.4% ANTI DIABETIC 1000 22.2% ANTI HTN 800 17.5%

  22. SYSTEMIC / METOBOLIC DISORDERS GROUP NO. OF PERCENTAGE CASES HTN 800 17.5% DM 700 15.5% CVD 750 16.6% HYPERLIPIDIAMIA 1000 22.2% THYROID 650 14.4% HARMONAL 600 13.3%

  23. DISCUSSIONS EXTENSIVE EDIDEMIOCOLOGICAL STUDIES CARRIED IN THE WORLD. ITS PRECISE AETIOLOGY IS UNKNOWN BUT MAY BE INCREASING OF LONGIVITY, CHANGE OF THE LIFE STYLE FOOD, HABITS, AND POLLUTION MAY CAUSE THE ARMD.

  24. MALES ARE SIGNIFICANTLY HIGHER THAN THE FEMALES.

  25. DRY TYPE OF ARMD IS HIGHER IN THIS STUDY

  26. URBAN PEOPLE [66.6%] ARE MORE INVOLVED THAN RURAL FOLK MAY BE POLLUTION, AND AWAY FROM THE NATURE

  27. AGEWISE DISTRIBUTION SHOWS THAT 70-79 YEARS WERE MORE AFFECTED THAN OTHER GROUPS MAY BE DUS TO SELEROTIC CHANGE, METOBOLIC CHANGES, AND RELATED CHANGES, LONGIVITY IS INCREASING AND ALSO PEOPLE MAY INCREASE 606 MILLION IN 2000 TO 1.2 BILLION BY 2025. JENNIFER EVANS 2008 SRINIVAS 2005

  28. IN THE SOCIO-ECONOMICAL GROUOP, HIGHER SOCIO ECONOMICAL GROUP WERE FOUND TO BE MORE THAN THE OTHER GROUPS MAY BE THEIR FOOD HABITS, LIFE STYLES.

  29. OCCUPATIONAL FACTOR SHOWS THAT EXECUTIVES ARE MORE INVOLVED THAN THEIR COUNTER PARTS

  30. FOOD HABITS WISE DISTRIBUTION HAS SHOWS THAT FATTY INTAKING PROPLE WERE MORE AMONG THEIR COUNTER PARTS, MAY BE CHOLESTROL INCREASING TENDENCY.

  31. IT IS OBSERVED INCIDENCE IS LOWER AMONG VEGETARIANS i.e., 44.5 MAY BE HIGHER CONTENT OF ANTIOXIDENTS, BETA-CARATENE, VIT-C AND SOME MICRO NUTRIENTS MAY HELP TO DELAY OR ARREST ARMD SRINIVAS-2009 SRINIVAS-1986

  32. VEGETARIAN IS COMMON IN INDIA AND 60% OF INDIAN AND 20% OF THE WORLD POPULATION ARE VEGETARIANS.

  33. LEO. TOLSTOY, ALBERT EINSTEIN, NEWTON, SHAKSPEAR, BERNARD SHAH, SOCRATES, AND GANDHI WEREVEGETARIANS.

  34. YOGA PRACTITIONERS ARE LESSER i.e., 44.5, THAN NON YOGA PRACTITIONERS MAY INCREASE THE 02 SRINIVAS 2001

  35. SMOKERS [53.3%] INVOLVEMENT IS HIGHER THAN NON SMOKERS, MAY INCREASE THE OXIDATIVE STRESS [HAMMOND. BR 1996]

  36. ALCOHOLICS [55.5%] ARE MORE THAN NON ALCOHOLICS

  37. AMONG MEDICATION HIGHER OF 22.2 IS SEEN IN THE ANTI DIABETIC DRUGS

  38. SYSTEMIC / METABOLIC DISORDERS, HYPERLIPIDAMIA IS THE HIGHER INVOLVEMENT i.e., 22.2% AMONG OTHER CONDITIONS.

  39. THANK YOU

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