ORAL BAD HABITS. Dr Suneel Kumar FCPS Assistant Professor OMFS Department LUMHS email@example.com. Dental Caries. Baby Bottle Syndrome Mother feed Milk Bottles Pacifier. Sweet supari (Betel Nut). Betel nut (Tree). Production Countries. Indonesia Malaysia Philippines India
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Dr Suneel Kumar
OMFS Department LUMHS
Oral Diseases (2011) 17 (Suppl. 1), 42–57
Cell turnover (By killing cells)
Reactive oxygen species
DNA Damage &
Reactive oxygen species
DNA & Fibroblast damage
Gingival blood flow
ORAL MUCOUS FIBROSIS
Oral Surg Oral Med Oral Pathol oral radiol 2010 :109:857-864
The International Agency for Research on Cancer (IARC) and the World Health Organization (WHO) accept the scientific evidence that chewing betel quids and areca nut is carcinogenic to humans. The main carcinogenic factor is believed to be areca nut. A recent study found that areca-nut paan with and without tobacco increased oral cancer risk by 9.9 and 8.4 times, respectively.
Oral leukoplakia more commonly occurs in those who smoke, but often the cause is unknown (hence the synonym idiopathic leukoplakia). Chewing tobacco is also associated with this type of lesion. Leukoplakia is a premalignant lesion, i.e. "a morphologically altered tissue in which cancer is more likely to occur than in its apparently normal counterpart". The chance of transformation into oral squamous cell carcinoma (OSCC, a type of oral cancer) varies from almost 0% to about 20%, and this may occur over 1 – 30 years. The vast majority of oral leukoplakias will not turn malignant, however some subtypes hold greater risk than others. No interventions have been proven to reduce the risk of cancer developing in an area of leukoplakia, but people are generally advised to stop smoking and limit alcohol consumption to reduce their risk. Sometimes the white patch will shrink and eventually disappear after stopping smoking, but this may take up to a year. In many cases, areas of leukoplakia will slowly expand, become more white and thicken if smoking is not stopped. Management usually involves regular review of the lesion to detect any possible malignant change early, and thereby significantly improve the prognosis, which normally is relatively poor for OSCC.