1 / 8

Pancreatic Enzyme Delivery (PED) Device

Pancreatic Enzyme Delivery (PED) Device. Group Members : Todd Dhavale Erica Osadzinski Advisor : Dr. Dennis Stokes. What is Cystic Fibrosis (CF)? . Inherited disease which causes exocrine (outward secreting) glands in the body to fail to function normally.

rebekah-mullins
Download Presentation

Pancreatic Enzyme Delivery (PED) Device

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Pancreatic Enzyme Delivery (PED) Device Group Members: Todd Dhavale Erica Osadzinski Advisor: Dr. Dennis Stokes

  2. What is Cystic Fibrosis (CF)? • Inherited disease which causes exocrine (outward secreting) glands in the body to fail to function normally. • Mucus-producing exocrine glands often produce thick, sticky secretions which plug-up ducts and other passageways. • This occurs in the lungs and intestines and interferes with breathing and digestion.

  3. Patients with Cystic Fibrosis: • Suffer from nutritional problems • Do not gain weight properly • Have improper pancreatic function • Need pancreatic enzymes to help digest food: • protease • amylase • lipase

  4. Effects of Cystic Fibrosis on Digestion • Occurs in 8 out of 10 of all CF patients • Pancreatic enzymes do not reach intestinal tract • Patients do not gain weight • Malabsorption occurs--growth impairment • Therefore, above average caloric intake is needed along with supplemental enzymes

  5. PED Device is designed to: • Deliver commercially available pancreatic enzymes directly to intestinal tract • Deliver enzymes to patients receiving overnight supplemental feedings via a gastrostomy tube

  6. Past Work: • Researched pancreatic enzymes function • Observed CF patients in Vanderbilt Children's Hospital • Assessed the current methods of obtaining the necessary pancreatic enzymes • Met with pharmacist for advice and recommendations

  7. Current Work: • Testing microsphere stability in the fluid delivery vehicle • Determining the minimum fluid vehicle volume necessary for overnight enzyme delivery • Investigating the capabilities of available pumps, both injection and peristaltic.

  8. Future Work: • Integrate pump fittings with connectors to gastrostomy tube (G-Tube) • Formulate limited Human Trials to evaluate the effectiveness of PED delivered enzymes • Obtain funding from Solvay Pharmaceutical to improve the current crude PED model

More Related