1 / 33

Mekanisme Kerja Hormon

Mekanisme Kerja Hormon. dr. Susila Sastri M.Biomed Biokimia FK- Unand. Hormone. Struktur Kimia Hormon. Polipeptida Insulin Glucagon Derivat asam amino ( amin ) Epineprin Serotonin Tyroxin. 3. Steroid ( derivat kolesterol ) Aldosteron Cortisol Retinoic acid

raven-dejesus
Download Presentation

Mekanisme Kerja Hormon

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Mekanisme Kerja Hormon dr. SusilaSastriM.Biomed Biokimia FK-Unand

  2. Hormone

  3. Struktur Kimia Hormon • Polipeptida • Insulin • Glucagon • Derivatasam amino (amin) • Epineprin • Serotonin • Tyroxin • 3. Steroid (derivatkolesterol) • Aldosteron • Cortisol • Retinoic acid • 4. Eicosanoid (polyunsaturated • acid, (20atom C) • Prostadglandin E • Thromboxane A2

  4. Simple Intracellular & Extracelluler Signaling

  5. Hormon Action

  6. Hypophise Anterior

  7. Neurohormone

  8. Cell Communication GAS MOLECULE

  9. Second messenger: Small molecules synthesized in cells in response to an external signal are the second messengers, which are responsible for intracellular signal transduction: Ca2+, DG, Cer, IP3,cAMP, cGMP

  10. Receptor Receptors: specific membrane proteins, which are able to recognize and bind to corresponding ligand molecules, become activated, and transduce signal to next signaling molecules: A. Membran B. Intra Sel Glycoprotein or Lipoprotein

  11. Kelenjer-Hormon-Target Sel Hypothalamus Nervous Releasing hormones Anterior pituitary Posterior pituitary Thyrotropin Somatotropin FSH Vasopressin Prolactin LH Oxytocin ACTH Adrenal Cortex Adrenal Medulla Thyroid Pancreas Ovary Testis Cortisol aldosterone Insulin, glucagon, somatostatin Estradiol Testosterone T3 Epinephrine Reproductive organs Muscles liver Liver, muscles Mammary glands Tissues

  12. 1. Membrane receptors

  13. Signal transduction mediated by membrane receptor • cAMP dependent-protein kinase A pathway • cGMP dependent PKG pathway • Ca2+ dependent PK pathway • Tyrosine protein Kinase pathway • NF-κB pathway • TGF- βpathway

  14. Membrane Receptor

  15. Cyclic AMP

  16. Mekanisme Signal Tranduksi

  17. 1 2 3 4 5 Hormon-2nd Massengger- Enzim Nitric oxide T-cell Activation Glucagon Insulin 1 3 4 5 2 G G G IP3 G Tyrosine kinase G protein Protein substrates Cyclic GMP Ca2+ Diacylgycerol Cyclic AMP Calmodulin PK-C PK-A PK-G Protein Ser/Thr kinases Protein substrates Protein substrates Multifunctional kinases End result is phosphorylation of one or more proteins Other phospholipases Protein substrates

  18. Inositol triphosphate System PLC; phospholipase C PIP2: phosphoinositol DAG:diacylgliserol IP3:inositol triphosphat PKC: phosphokinase C

  19. Intracellular receptor (DNA transcription regulated receptor) Steroid Hormone, VD3, Thyroxine • Cytosolic R: glycocorticosteroid H • Nuclear R: thyroxine, estrogen, androgen, progesterone

  20. Hormon - Receptor • highly specificity • highly affinity • saturation • reversible binding • special function model

  21. Control of receptor activity • Phosphorylation or dephosphorylation of R • Phospholipid of membrane • Enzyme catalyzed hydrolysis • G protein regulation

  22. Thyroid Mechanism of Action

  23. Adrenaline Mechanism of action

  24. ACTH Mechanism of Action

  25. Aldosteron Mechanism of Action

  26. Estrogen Mechanism of Action

  27. Androgen Mechanism of Action

  28. Insulin Receptor

  29. Insulin Action

  30. Glucagon

  31. GH/ STH

More Related