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Role of Dopamine Transmission in Drug Abuse Mechanism in Animal Studies

Animal studies suggest that cocaine, morphine, nicotine, and ethanol increase dopamine transmission in the BNST, possibly through interactions with neuronal circuits linked to natural reinforcers, indicating a role in drug abuse and addiction mechanisms. This work explores the phenomenon further.

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Role of Dopamine Transmission in Drug Abuse Mechanism in Animal Studies

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  1. What do we know about addictive drugs from animal studies? “… cocaine, morphine, nicotine, and ethanol share the property of increasing DA transmission in the BNST. This effect may be related to an action at the level of neuronal circuits activated by natural reinforcers … suggest[ing] that DA transmission of the BNST plays a role in the mechanism of drug abuse and addiction.” Carboni, … DiChiara et al. J Neurosci 20:RC102(1-5), 2000

  2. aaarrrggghhhh!!!!! – show me DBP

  3. what phenomenon is this?

  4. No CS unexpected reward from: Schultz, Dayan, & Montague, 1997, Science. CS predicted reward CS absence of predicted reward

  5. does everyone understand what they are showing here?

  6. -12 -2 40 50 de-nic cig nic cig

  7. mu

  8. mu D2

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