1 / 31

musicground.br

www.musicground.com.br. www.xenomed.com/.../26306-plastination.html acessado 01/08/2008. Coração pathology.mc.duke.edu/research/PTH225.html. Alterações celulares reversíveis X irreversíveis. Ponto de não retorno. Necrose. Necrose – morte no organismo vivo. Porém é um termo errado.

rance
Download Presentation

musicground.br

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. www.musicground.com.br

  2. www.xenomed.com/.../26306-plastination.html acessado 01/08/2008 Coração pathology.mc.duke.edu/research/PTH225.html

  3. Alterações celulares reversíveis X irreversíveis Ponto de não retorno

  4. Necrose Necrose – morte no organismo vivo Porém é um termo errado...

  5. Necrose por coagulação ou isquêmica Bogliolo Patologia. Geraldo Brasileiro Filho – 7a. edição

  6. Necrose liquefativa cérebro abscesso

  7. NECROSE GORDUROSA

  8. Necrose caseosa Bogliolo Patologia. Geraldo Brasileiro Filho – 7a. edição

  9. Outras: .hemorrágica .gomosa .fibrinóide .gangrena

  10. APOPTOSE

  11. MORFOLOGIA DO NÚCLEO www.cyto.purdue.edu/.../data/malorni/malorni.htm em 25/FEV/2008

  12. Figure 1A is a photomicrograph of a section of exocrine pancreas from a mouse. The arrows indicate apoptotic cells that are shrunken with condensed cytoplasm. The nuclei are pyknotic and fragmented. Note the lack of inflammation. The apoptotic cell appears as a round or oval mass with dark eosinophilic cytoplasm and dense purple nuclear chromatin fragments Toxicol Pathol. 2007 ; 35(4): 495–516

  13. Bid Robbins & Cotran. PathologicBasis of Disease, 2004.

  14. Kroemer G, Galluzzi L, Brenner C. Mitochondrial Membrane Permeabilization in Cell Death. Physiol Rev 87:99–163, 2007.

  15. Mol Neurobiol (2010) 42:4–9

  16. APOPTOSE - VIA EXTRÍNSECA TRAIL TRAIL APO3 FasL DR3 TRADD DR4 (TRAIL-R1) DR5 (TRAIL-R2) TRAF2 RIP FADD JNK IKK Caspase 8 e 10 NF-kB AP1 XIAP FLIP Bcl-2

  17. Bogliolo

  18. Um processo contínuo Necrose ---- Apoptose

  19. Morte Celular Programada Necrose . . . . . . Apoptose (tipo I) Autofagia (tipo II) Catástrofe mitótica... outros.... Netose

  20. Autofagia Tipos Mecanismo fisiológico Forma de Morte Celular Excesso: Imunodeficiência da AIDS Deficiência: Envelhecimento Alzheimer D. Parkinson D. Huntington

  21. nutrientes estresse fatores de crescimento Autofagia - PIP3 P53 IGF-1–AKT TOR MDM2 + + Raptor sensível rapamicina Rictor Ativa substratos anti-apoptóticos Ativa ciclo-celular Parada do ciclo celular Reparo Senescência Apoptose regulação crescimento celular reorganização citoesqueleto

  22. Netose / Etose (neutrophil extracellular traps)

  23. 2009; 30 (11) 513-521

  24. Restrição Calórica Há que ser comprovada no homem Como prevenir o envelhecimento?

  25. “We have presented evidence that the age-dependent decrease in abundance and bioenergetic competence is considerably attenuated in mitochondria of the long-lived daf-2 mutant animals, and that these changes are associated with a higher membrane potential and increased ROS production. We also showed that the ultimate mechanism by which the daf-2(e1370) mutation extends life span cannot be ascribed to the higher standing levels of ATP or reduced oxidative damage”.

  26. Mecanismos: Autofagia . Deprivação calórica aumenta Sirtuínas Deacetilases dependentes de NAD - um elo de ligação entre a energética da célula e sua longevidade - ↑ jejum TRENDS in Pharmacological Sciences Vol.26 No.2 February 2005

  27. Sirtuínas Resveratrol ↑ sirtuínas Cell. 2008 January 25; 132(2): 171–176.

  28. Nature - published online 8 July 2009

  29. nutrientes estresse fatores de crescimento Autofagia - PIP3 P53 IGF-1–AKT TOR MDM2 + + Raptor sensível rapamicina Rictor Ativa substratos anti-apoptóticos Ativa ciclo-celular Parada do ciclo celular Reparo Senescência Apoptose regulação crescimento celular reorganização citoesqueleto

More Related