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Ibogaine and cellular metabolism

Ibogaine and cellular metabolism. Traditional use of Iboga. e nteogen - ritual drug oneirogen - awake dreams p s ychostimulant and tonic re c onvalescenc e after infec tious diseases aph rodi s ia c. Use of Iboga/ibogaine in the West.

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Ibogaine and cellular metabolism

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  1. Ibogaine and cellular metabolism

  2. Traditional use of Iboga • enteogen - ritualdrug • oneirogen - awake dreams • psychostimulant and tonic • reconvalescenceafter infectiousdiseases • aphrodisiac

  3. Use of Iboga/ibogaine in the West • interruption of addiction to alcohol, opiates, nicotine in cocaine • spiritual growth and self-realization • holly sacrament • use at extreme sports– mountaineering • interesting for army

  4. Ibogaine in medicine • 1905: 10–30mg per day against asthenia • 1939-1970: neuromuscular stimulant 8mg per pill against fatigue, depression and at reconvalescence after infectious diseases • 1969: 4-5mg/kg as fantasy enhancer at psychotherapy

  5. Pharmacodynamics of ibogaine • immediate (acute) effect • prolonged effect

  6. Pharmacodynamics of ibogaine • effects last longer than the presence of ibogaine in the body • fat deposits of lipophillic metabolite cannot directly cause the effect for weeks or months • functional and structural changes are expected

  7. Composition of cell • nucleic acids • proteins • polysaccharides • lipids • water

  8. Proteins • structural • functional

  9. Structural proteins-cytoskeleton

  10. Functional proteins-receptor

  11. Functional proteins-enzyme

  12. Protein separation by 2-D electrophoresis

  13. Computer scan of gel

  14. Computer scan of gel

  15. “In silico” analysis of results

  16. Spots of interest

  17. Peptide mapping by mass spectrometry

  18. Identification of proteins by matching with data bases

  19. Induction of energy metabolism related enzymes in rat brain

  20. Induction of energy metabolism related enzymes

  21. Nonspecific activation of metabolism

  22. Interpretation of results Enhanced energy availability supports higher metabolic turnover and by that facilitates detoxification and renewal of tissues. Besides, consequent mental agility provides insight into one’s own psychological state

  23. Aura and ibogaine -40 min +3 h +54 h

  24. Aura and ibogaine

  25. Aura and ibogaine –thantanosis

  26. Aura and ibogaine

  27. Aura and ibogaine

  28. Aura and ibogaine Maybe illumination and revelation are proper words to describe what is at this moment difficult to explain

  29. Pharmacodynamics of Entheogen Drugs - Influence on Gene Expression - Faculty of Pharmacy, UL - Biotechnical Faculty, UL - Faculty of Medicine, UL - Faculte de Pharmacie, Universite Montpellier 1, Montpellier, France - Institute for Biological Research Siniša Stankovic, Belgrade, Serbia OMI,Institute of Anthropological Medicine www.omi.si

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