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Synthetic siRNA are also known as short interfering RNA, which is a type of non-coding double stranded RNA of 20-23 nucleotide base pairs in length. It is a powerful tool used for modulating gene expression by RNA interference (RNAi).siRNAs consist of two RNA strands, an antisense (or guide) strand and a sense (or passenger) strand, which form a duplex 19 to 25 bp in length with 3' dinucleotide overhangs. siRNA are transfected into cells by using delivery methods like polymer-based transfection reagents, electroporation or by adding chemical modifications.
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