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Corona Viruses

Corona Viruses. fackrel@Uwindsor.ca Corona.ppt. Corona Viruses. Structure Classification Multiplication Clinical manifestations Epidemiology Diagnosis Control. Baron’s Web Site. Structure. Spherical or pleomorphic 80-100 nm Enveloped club shaped glycoprotein spikes

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Corona Viruses

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  1. Corona Viruses fackrel@Uwindsor.ca Corona.ppt

  2. Corona Viruses • Structure • Classification • Multiplication • Clinical manifestations • Epidemiology • Diagnosis • Control Baron’s Web Site

  3. Structure • Spherical or pleomorphic 80-100 nm • Enveloped • club shaped glycoprotein spikes • ss RNA sense strand

  4. Classification • Crown of envelope glycoproteins • 2 serotypes • OC43 like • 229E like

  5. Multiplication • Virus enters nasal epithelium • Uncoats • ssRNA transcribed >>> translated • mRNA nested set • common 3’ ends • only unique portion of 5’ translated

  6. Common Cold mild, acute upper respiratory tract infections Clinical Manifestations Diarrhea in children RARE!

  7. DISEASE Interferon Virus antibody Time (days) Corona Virus Pathogenesis coryza Nasal Secretions Nasopharynx

  8. Epidemiology • local epidemics • Peak incidence in Winter • last few weeks- months

  9. Diagnosis • Clinically • undistinguished from other colds • Laboratory • increase in antibody titre over time • virus difficult to isolate

  10. Control • Treat symptoms • Improve hygiene • No vaccines • No specific antivirals

  11. DONE!!!

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