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Thyroid-Directed Gene Transfection for Lung Disease Treatment

Explore gene transfection targeted at the thyroid to treat lung diseases. This innovative approach involves utilizing specific genes for beneficial effects. Learn more about the potential therapeutic application and genetic modifications for improved treatment outcomes.

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Thyroid-Directed Gene Transfection for Lung Disease Treatment

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  1. ~12Kb ATG TGA B B B B B B B B B B B PGKneo PGKneo PGKneo P P P 12Kb 4.5Kb pA pA 8.5Kb 4.5Kb C A DCOOH/DCOOH DNH2/DNH2 PM/PM /DCOOH AD1 +/PM AD2 /DNH2 wt wt wt P P P P P P P Nkx2-1 P P P P 1 372 DNH2 372 159 DCOOH 1 221 D 1 372 PM /DCOOH DCOOH /DNH2 wt DNH2 wt B pr Wt Wt Mutant Transfected cells Thyroid DNH2 pA E - + - + 1 2 3 4 phosphatase DCOOH native dephosphorylated PM PM/PM lung WT lung

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