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Allows a new type of organ transplantation Living organ transplant Maintains organs in warn functioning state outside of the body Hearts beat Lungs breath Kidneys produce urine Livers produce bile . Simulates conditions of the human body and allows the organ to function as it normally would
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Allows a new type of organ transplantation • Living organ transplant • Maintains organs in warn functioning state outside of the body • Hearts beat • Lungs breath • Kidneys produce urine • Livers produce bile
Simulates conditions of the human body and allows the organ to function as it normally would • Donor blood • Warms the organ as needed • Protects against contamination
House all elements of the system • Oxygen supply • pump • Battery (transportation) • Digital screen for monitoring • Aortic pressure • Heart rate
Sterile chamber • Protects the heart • Maintain temperature and humidity • Enables sterile ultrasound and blood sampling
Provides nutrients to the organ they would normally receive in the body • Keeps the organ healthy during transplant
Ischemic organs are cooled below normal temperature with fluids and ice to minimize cell death • The more times that passes the more damage • After certain time the organ becomes unusable • Most hearts transplanted in four hours • Many organs go unused because of this • Because organs are transplanted non-functioning underlying diseases or damage due to transplantation can not be detected
Around 2,000 people receive heart transplants every year • 400 will die while waiting for a transplant • Donor hearts can last roughly four hours before they become unusable
Two catheters are inserted into the heart • Aorta (blood enters) • Pulmonary artery • Aorta is attached to inflow • Inferior and superior vena cava, all other veins and arteries are all stitched closed so all the blood leaves through the pulmonary artery
Blood leaves through the pulmonary artery • Passes through the oxygenator • Pumped through the heating element • Enters the heart through the aorta
Increase the amount of time the organ can maintain outside of the body • Provides surgeons the opportunity to assess the organ outside of the body • Improve function of the organ after removal
Typically, 92 to 95 percent of heart transplant patients are alive and their new heart is working after 30 days • Clinical trials in Europe, which concluded four years ago, showed 30-day survival rates for patients who received beating heart transplants were almost 98 percent.
Primary outcomes • Increase 30 day survival rate of heart transplant patients • Secondary outcomes • Decreased ICU stay • Heart related adverse events • Rejection • Heart defects
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