Nadia Roan, PhD International AIDS Meeting 2012 July 23, 2012 - PowerPoint PPT Presentation

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Nadia Roan, PhD International AIDS Meeting 2012 July 23, 2012 PowerPoint Presentation
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Nadia Roan, PhD International AIDS Meeting 2012 July 23, 2012
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Nadia Roan, PhD International AIDS Meeting 2012 July 23, 2012

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  1. The Effect of Liquefaction on the Ability of Semen and Semen Amyloid Fibrils to Enhance HIV Infection Nadia Roan, PhD International AIDS Meeting 2012 July 23, 2012

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  8. During semen liquefaction, PSA specifically cleaves SEM proteins

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  11. Summary • Fragments from semenogelins form amyloid fibrils and enhance HIV infection

  12. Summary • Fragments from semenogelins form amyloid fibrils and enhance HIV infection • Semen samples naturally defective in semenogelins do not enhance HIV infection

  13. Summary • Fragments from semenogelins form amyloid fibrils and enhance HIV infection • Semen samples naturally defective in semenogelins do not enhance HIV infection • Semen that has undergone prolonged liquefaction has diminished ability to enhance HIV infection. The “window of opportunity” for viral enhancement activity is >8 hours post-emission

  14. Acknowledgements Gladstone Institute of Virology and Immunology Warner Greene Simon Chu Greene Lab Members University of California, San Francisco Ewa Witkowska Haichuan Liu University of Ulm Frank Kirchhoff Jan Münch Janis Müller A.P. Giannini Medical Research Foundation 1PO1 AI083050-01 PPG Department of Defense #10113005

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  20. J. Müller, J. Münch

  21. J. Müller, J. Münch