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Slacker’s Guide to Neurotransmitters

Slacker’s Guide to Neurotransmitters. Prepared by Mike Ori. Disclaimer. Slackers please continue but note… The summary was taken from our class notes and PowerPoint slides. They reflect my understanding and could be wrong. The faculty has in no way vetted this document.

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Slacker’s Guide to Neurotransmitters

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  1. Slacker’s Guide to Neurotransmitters Prepared by Mike Ori

  2. Disclaimer • Slackers please continue but note… • The summary was taken from our class notes and PowerPoint slides. They reflect my understanding and could be wrong. • The faculty has in no way vetted this document. • I’m really uncertain of anything with (?) or in red. • If you see something wrong, let me know. If you’re a gunner, shame on you for looking at this. Do your own work.

  3. Key Increase A lot A lot Decrease A lot is relative. I used it when there were (++) indicators in the text.

  4. CNS Memory Sleep Dementia Delirium Alzheimer Awake PTSD Autism Slow Wave Sleep Basal N. ARAS REM Sleep Cholinergic Basal Nucleus ARAS Choline Acetate ACh Choline Acetyltransferase Cord/interneurons PNS Parasympathetic Sympathetic Skeletal Ganglion Ganglion NMJ Myasthenia Gravis* Muscarinic Effector *Net effect is as if there is a decrease in Ach

  5. CNS Well Being Movement ADHD? Schizophrenia Huntington Addiction Parkinson VTA SNC Dopaminergic Ventral tegmental Area SubstantiaNigra Catecholamine Tyrosine L-DOPA Dopamine Tyrosine Hydroxylase (Limiting) DOPA Decarboxylase (Carbidopa inhibits) Parasympathetic PNS Sympathetic Skeletal None detailed in class but peripheral effects of PD treatment cause GI upset.

  6. CNS Well Being OCD Eating Disorders Depression Anxiety Tourette Raphe Serotonergic AKA: 5-HT Raphe nuclei Tryptophan Serotonin Tryptophan Hydroxylase (Limiting) Parasympathetic PNS Sympathetic Skeletal Descending pain modulation by GABA disinhibition of PAG

  7. CNS Well Being Memory Sleep ADHD Depression PTSD Awake Slow wave sleep Anxiety LC Adrenergic Locus Ceruleus Catecholamine REM Sleep Tyrosine … Norepinephrine … Tyrosine Hydroxylase (Limiting) PNS Parasympathetic Sympathetic Skeletal Ganglion Descending pain modulation by GABA disinhibition of PAG None described in class Effector

  8. CNS Thalamic Reticular Cortical Regulation Well Being inattentive Seizure Anxiety Gabaergic Increase GABA to slow brain activity If its inibited, think GABA Glutamate GABA Glutamic acid decarboxylase (Limiting) PNS Parasympathetic Sympathetic Skeletal Descending pain modulation by GABA disinhibition of PAG. Most likely neurotransmitter in any inhibitory synapse

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