How many patients does case series should have In comparison to case reports

1. How many patients does case series should have? In comparison to casereports An Academic presentationby Dr. Nancy Agnes, Head, Technical Operations, Pubrica Group: www.pubrica.com Email:sales@pubrica.com

2. TODAY'SDISCUSSION Outline Inbrief Introduction When to consider a CaseSeries? When is a High Acceptance Rate Possible? Merits andDemerits Criteria Conclusion About Pubrica References

3. INBRIEF The area of medical research is constantly developing, with more data being collected everyday. Several studies in clinical research have been classed as descriptive oranalytic. Cross-sectional research, ecological correlational studies, case report writing, case series report writing, and surveillance studies are examples of descriptivestudies. Contd...

4. On the other hand, analytical investigations to investigatea hypothesis concerning a causal link between exposure andresult. Because this article focuses on case reports and case series, the analysis will be limited to only those types ofresearch.

5. INTRODUCTION The clinical case reporthas a longstanding tradition in the medical literature. While the scientific value of case reports has diminished as more modern research methods have gained traction, they are still published in many medicaljournals. Some researchers argue that it has minimal relevance for medical advancement, while others say it isunderestimated. We hoped to give multiple perspectives on the benefits and drawbacks of the case reportgenre. Contd...

6. A case report typically consists of one or two cases. A case series or case series report typically includes three to 10 cases. Naturalistic and descriptive case reports are the mostcommon. They can, however, be speculative and experimental at times. Recognizing innovations is arguably the most significant advantage of casereporting. It is the sole means to report unexpected, uncontrolled observations on symptoms, clinical findings, illness progression, complications of therapies, disease linkages, pharmacological side effects, and soon. In summary,anythingunusualorpreviouslyunseenmaybeessentialforthemedicalcommunityand should bedisclosed. A case report may sensitize readers, making it easier to discover similar or identicalinstances.

8. WHEN TO CONSIDER A CASESERIES? If you plan to publish your medical case study report writing and case series, keep in mind that your reports should be the first to document medical breakthroughs, such as reportingrare diseases in recognizing adverse or beneficial outcomes of intervention or novel diagnostic or therapeuticstrategies. Furthermore, the major goal was to develop ideas that might be investigated in future research with higher methodological rigour. Contd...

9. As a result, case series may be used to evaluate therapy safety and diagnostic accuracy, and no control group is required with appropriate long-termfollow-up. There is a requirement for preliminary evidence to build the notion that a therapy maybe beneficial to have your research financed. In this scenario, these reports are frequently the first level ofevidence.

10. WHEN IS A HIGH ACCEPTANCE RATE POSSIBLE? A case series generally incorporates information gathered from multiple sources and includesone or more specifics about the disease, treatment, diagnostic procedures, and so on, whereas a case report has much less data and may consist of detailed demographicinformation. Acceptance of the case series takes longer than acceptance of the case report by anypublisher. Case reports are professional narratives that give feedback on clinical practice standards, a framework for adverse occurrences, and early cost and effectivenessindicators.

11. MERITS ANDDEMERITS Bothcase series and best-case report writinghave advantages and disadvantages. Case series are extremely valuable in rare cases where a new type of sickness or ailment impacts theperson. Furthermore, the publishers may make a few concessions while assessing a case series because of the biased content based on the editors' personalbeliefs. Moreover, case series have excellent external validity, little influence on the treatment choice process, a diverse variety of patients, and areaffordable. Contd...

12. In terms of limitations, the clinical case study report writinglacked comparison groups, and data collection was frequently insufficient, prone to bias, selection bias, and measurement bias. Case reports, on the other hand, enable healthcare practitioners to comprehend the instances and take less time tocreate. However, case reports may not contain all the pertinent and minute facts required to treat the individuals. A case series does not use randomization, making it more efficient andcost-effective.

13. Table 1: Role of case reports/series in the medicalliterature

14. CRITERIA Afewcriterianeedtobefollowed whenever acaseseriesis developed. Title - Include the terms "case series" and the area of concentration in thetitle. Abstract - Introduction -Emphasize the case series' unifying theme. Methods – what was done, how andwhen. Results – what was found. Conclusion – what we havelearned. Introduction – emphasize the scientific background andrationale. Design –the research registry number (ResearchRegistry.com or ClinicalTrials.gov or ISRCTN) list the intended population, process manner, and endoutcome. Analysis–Whileanalyzing,descriptivestatisticsandtechniquesmustbeemployed,andno comparison tests yielding p values should beperformed. Reporting–Everyfollow-upinacaseseriesmustprovidethetopicinformationandprogress, comprehensive details, andanalysis.

15. Table 2: Tool for evaluating the methodological quality of case reports and caseseries

16. CONCLUSION In the clinical research arena, both case series and case reports are intended for use by healthcare practitioners. Aside from the differences between a case series and a case report, they provide reliable information with prompt intervention. If both are adequately prepared from the start, they can even be used as alternatives to another level of studies with greater confidence than theformer. Reporting case series in a uniform and statistically suitable manner would allow for accurate interpretation and future meta-analyses to provide long-term outcomeestimates.

17. ABOUTPUBRICA Pubrica's team of researchers and writers create scientific and medical research articles, which may be important resources for authors andpractitioners. Pubrica medical writers assist you in creating and revising the introduction by alerting the reader to gaps in the chosen study subject. Our professionals understand the order in which the hypothesis topic is followed by the broad subject, the issue,and the backdrop.

18. REFERENCES Konala, V. M., Adapa, S., Naramala, S., Chenna, A., Lamichhane, S., Garlapati, P. R., … &Gayam, V. (2020). A case series of patients coinfected with influenza and COVID-19. Journal of investigative medicine high impact case reports, 8,2324709620934674. Tahvildari, A., Arbabi, M., Farsi, Y., Jamshidi, P., Hasanzadeh, S.,Calcagno, T. M., … &Mirsaeidi, M. (2020). Clinical features, diagnosis, and treatment of COVID-19 in hospitalized patients: a systematic review of case reports and case series. Frontiers in medicine, 7,231. Nissen, Trygve, and Rolf Wynn. "The clinical case report: a review of its merits and limitations." BMC research notes 7.1 (2014):1-7.

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