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A meta-analysis of biotechnology genome-wide association data – Pubrica

This blog reviews a meta-analysis combining data from genome-wide association studies by Liu and Youfang and coordinating with Blackwood (2009) for ascertainment and diagnostic assessment genotyping quality control and analysis.<br><br>Reference : https://bit.ly/3sJOi0B<br>Our services : https://pubrica.com/services/research-services/meta-analysis/<br>

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A meta-analysis of biotechnology genome-wide association data – Pubrica

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  1. BIPOLARANDMAJOR DEPRESSIVEDISORDER: AMETA-ANALYSISOF BIOTECHNOLOGYGENOME- WIDEASSOCIATIONDATA AnAcademicpresentationby Dr.NancyAgnes,Head,TechnicalOperations,Pubrica Group:www.pubrica.com Email:sales@pubrica.com

  2. TODAYSDISCUSSION Inbrief Introduction EvidenceSupportContinuityBetweenMajor DepressiveDisorderandBipolarDisorders Factorsofhypomaniainmajordepressive disorder Conclusion AboutPubrica

  3. INBRIEF The Significant indirect evidence demonstrates that bipolar disorder (BIP) and major depressive disorder (MDD) are related (MDD). BIP and MDD havemajordepressive episodesincommon; however, BIP is characterised by manic (bipolar 1)orhypomanicepisodesinBIP(bipolar2). Meta-AnalysisWritingServicesConsidering overlap between genetic risk variables for both illnesses, genetic epidemiological and genome- widelinkagestudiesare also consistentto discovercommongeneticriskfactors.

  4. Tofindcommongeneticriskfactors,researchersconductedasurvey. This blog reviews a meta-analysis combining data from genome-wide association Blackwood studies (2009) byLiuandYoufangandcoordinatingwith forascertainmentanddiagnosticassessment genotypingqualitycontrolandanalysis.

  5. INTRODUCTION Recentresearch approaches that haschallengedconventionaldiagnosis divide mood disorders into two distinct categories:bipolaranddepressivedisorders. The present taxonomy of mood disorders opposes Kraepelin's concept ofmanic-depressiveinsanityasasingleentity (illness). Recentstudyfindingsimplyarelationshipbetweenbipolar disorders(particularlybipolarIIdisorder) and major depressive disorder. Thefollowing features currently point to alinkbetweenbipolarIIdiseaseandmajordepressive disorder:

  6. Mixeddepressivestates(mixeddepression)anddysphoric(mixed)hypomania (oppositepolaritysymptomsinthesameepisodedonotsupportmooddisorder splitting); Familyhistory(majordepressivedisorderisthemostcommonmooddisorderin relativesofbipolarprobands); Lackofpointsofequivalence betweenthedepressive syndromes of bipolar II disorderandmajordepressivedisorder; Bipolarmajordepressiveillnesswithdepressionmixedstates, early-onset age, atypicalcharacteristics,bipolarfamilyhistory, irritability,racingthoughts,and psychomotoragitation;

  7. Ahighproportionofmajordepressivedisordersshifttobipolardisordersduringlong- termfollow-up; Alargeproportionofpeoplewithseriousdepressionhaveahistoryofmanicor hypomanicsymptoms; Factorsofhypomaniapresentinmajordepressivedisorderepisodes; Therecurrentcourseofmajordepressivedisorder;and Depressivesymptomsaremuchmorecommon symptomsinthestudyofbipolardisorders. than manic and hypomanic

  8. BETWEENMAJORDEPRESSIVE DISORDERANDBIPOLAR EVIDENCESUPPORTCONTINUITY DISORDERS BipolardisorderbipolarIIisthemostsimilarto majordepressivedisorder. Asaresult,Meta-AnalysisExpertspursuing consistencyfocusedontheconnections between thesetwoillnesses. There are some similarities between bipolar II illness andmajordepressivedisorder.

  9. Theproceduresfordetermining,diagnosing,genotyping,qualitycontrol,and analysisaredescribedelsewhere. Bothinvestigations were carried outwiththe necessary ethical permissions, and allparticipantsgavewritteninformedconsent. Themajorityofcases(81%)fulfilledDSM-IV(DiagnosticandStatisticalManual of Mental Disorders-IV) bipolar 1 criteria, with a lesser proportion (16%) fulfilling criteria for bipolar 2 (16%), schizoaffective disorder/manic type (2%), or bipolar NOS(nototherwisespecified)criteria(1%).

  10. Singlenucleotidepolymorphisms(SNPs)wereevaluatedafterqualitycontrol (18.7%weregenotypeddirectly,andtherestwereimputed). Cases satisfying DSM-IV (Diagnostic and Statistical Manual of Mental Disorders- IV) criteria for MDD were found in clinical and communitysources, while controls withlowMDDriskwerechosenfromapopulationsample. Excessivemissingness, uncommongenome-wideheterozygosity,andfirst-or second-generationmutationswereallreasonsforsubjectsbeingexcluded.

  11. Depressive mixedstateswereseenin around 30% of depressiveillness. individualswithmajor Apartfromtheraisedmoodfactor,the factorstructureofhypomania(outside depression)wascomparabletothatof depressedmixedstates. FACTORSOF HYPOMANIAINMAJOR DEPRESSIVEDISORDER

  12. In depressive diverse states (of major depressive disorder and bipolar II disorder), two hypomanic factors were found: the most common was a mental activation factor, which included racing and crowded thoughts and irritability, and the other was a motor activation factor,whichincludedpsychomotoragitationandmoretalkativeness. The occurrence of hypomania aspects inside the depression of major depressive disorder suggeststhatbipolarIIdisorderandmajordepressivedisorderareassociated. It was found that depression and depressive symptoms were much more common than mania, hypomania, and manic and hypomanic symptoms in bipolar disorders (especially bipolarIIdisorder).Thisfindingsupportsalinkbetweenbipolardisordersandmajor depressivedisorder

  13. CONCLUSION CACNA1Criskpolymorphismsmay have a roleinbipolarandunipolar majormood disorders,accordingtotheseClinicalMeta- AnalysisExperts. Accordingtocertaintheories, genetic variationinCACNA1Cmightbeafrequent, modest,andpleomorphicrisk factor for mentaldisorders.

  14. Alternatively, the overlap might be due to misclassification—for example, if some MDD patients were actually "bipolar-like" but were misclassified owing to diagnostic ornosologicalmistakes(despiteusingconventionalandmeticuloustechniques),or ifsomeBIPpatientsweresimilarlymisclassified. The bipolar risk locus ANK3, on the other hand, received no support in this meta- analysis,indicatingthatitseffectmaybelimitedtoBIPorthatthepowertodetect aneffectwaslow.

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