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The physiology and biochemistry of the Paleolithic Diet for weight reduction. David C. Pendergrass, Ph.D. University of Kansas. Glycolysis to Lipogenesis. TRPV1 Hypothesis. Nociceptor. Sensory Neuron. monocyte. β - cell. TRPV1 – Physiological Mediator. Nociception Inflammation

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the physiology and biochemistry of the paleolithic diet for weight reduction

The physiology and biochemistry of the Paleolithic Diet for weight reduction

David C. Pendergrass, Ph.D.

University of Kansas

slide3

TRPV1 Hypothesis

Nociceptor

Sensory Neuron

monocyte

β- cell

trpv1 physiological mediator
TRPV1 – Physiological Mediator
  • Nociception
  • Inflammation
  • Infection
  • Immunity: Exposure to TRPV1 agonists
    • Keratinocytes  PGE2 & IL-8
    • PBMC  apoptosis
  • Alimentary tract:
    • Metabolism
    • Hair growth regulation
    • Cancer development
  • Reduced obesity
  • Smooth muscle cell regulation
  • Anorexigenic signaling
trpv1
TRPV1 -
  • Agonists
    • Thermosensing >43C; pain
    • Protons (pH < 5.2)
    • Capsaicin
    • Depolarizing voltage > + 60 mv (outwardly rectifying)
    • Stretch
trpv11
TRPV1 -
  • Sensitizing molecules
    • 17-β-estradiol
    • Anandamide
    • Olvanil
    • Omega-3 polyunsaturated FA
    • 12-hydroperoxyeicosatetranoic acid (12-HPETE)
    • N-arachidonyl dopamine (NADA)
    • 2-aminoethoxydiphenyl borate (2-APB)
    • Inflammatory mediators
      • Growth factors
      • Neurotransmitters: bradykinin, serotonin, histamine, prostaglandins
      • Peptides and small proteins
      • Lipids
      • Chemokines
      • Cytokines
    • Intracellular phosphorylation
      • PKC
      • PKA
      • Tyrosine receptors kinases
      • Ca2+/CAM Kinase
trpv12
TRPV1
  • Desensitizing molecules
    • PIP2
sing a long
Sing-a-long
  • If you’re healthy and you know it:
  • If you’re healthy and you know it, Modern People gotta show it, if you’re healthy and you know it:
  • Eat GOOD meat
  • Don’t eat wheat
  • Eat GOOD fish
  • Make the switch
  • Eat your greens
  • Buy new jeans
bibliography
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