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Tissue Deposits and Growth Abnormalities

Tissue Deposits and Growth Abnormalities. 1. Gross. 1. Kidney atrophy Ischemia lead to a compensatory decrease in size (atrophy) of one kidney. The atrophy primarily involves the cortex, which contains the most metabolically active cells.normal kidney to the right, kidney atrophy to the left.

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Tissue Deposits and Growth Abnormalities

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  1. Tissue Deposits and Growth Abnormalities

  2. 1. Gross 1. Kidney atrophyIschemia lead to a compensatory decrease in size (atrophy) of one kidney. The atrophy primarily involves the cortex, which contains the most metabolically active cells.normal kidney to the right, kidney atrophy to the left

  3. 2. Microscopy Normal Lung: mostly empty space. Alveoli have thin wall less than 1 micron. The alveolar wall has a thin epithelial cell through which oxygen and carbon dioxide diffuse into the capillary lumen 1. Metastatic calcification in the lung: Here is so-called "metastatic calcification" in the lung of a patient with a very high serum calcium level (hypercalcemia). Calcification appear as blue granules.(Characteristic features)

  4. 2. Muscle fiber atrophy There are some muscle fibers here that show atrophy. The number of cells is the same as before the atrophy occurred, but the size of some fibers is reduced. This is a response to injury by "downsizing" to conserve the cell. (Pathological characteristics)

  5. Normal thyroid glandThe thyroid follicles have a single layer of low cuboidal epithelium surrounding a central collection of colloid. The follicles are round to oval, vary somewhat in size, and appear closely packed. 3. Thyroid gland hypertrophy and hyperplasia: In contrast to the previous image, the epithelial cells here are tall columnar (hypertrophy). The cells have also proliferated (hyperplasia), causing them to become crowded. Consequent folding into the follicle lumens has formed papillary projections. (Characteristic features)

  6. Questions • 1- Name of the spot- • 2- What are the pathological features of the specimen ?

  7. Questions 8 1- Name of picture B. 2- What are the pathological features of this specimen? B A

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