What Are Side Effects of Tacrolimus?

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2. What is TACROLIMUS? • Tacrolimus weakens your body's immune system, to help keep it from "rejecting" a transplanted organ such as a kidney. Organ rejection happens when the immune system treats the new organ as an invader and attacks it. • Tacrolimus is used together with other medicines to prevent your body from rejecting a heart, liver, or kidney transplant. • Tacrolimus may also be used for purposes not listed in this medication guide. • Warnings • Tacrolimus may increase your risk of developing a serious infection, lymphoma, or other cancers. Talk with your doctor about the risks and benefits of using tacrolimus. • Call your doctor right away if you have any signs of infection such as fever, chills, flu symptoms, cough, sweating, painful skin sores, skin warmth or redness, or muscle aches. • Before taking this medicine • You should not use this medicine if you are allergic to tacrolimus or hydrogenated castor oil, or if • you have used cyclosporine (Neoral, Sandimmune, Gengraf) within the past 24 hours. Source : https://www.drugs.com/mtm/tacrolimus-oral-and-injection.html

3. How should I take TACROLIMUS? • Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed. • You may receive an injection of tacrolimus shortly after your transplant. Tacrolimus injection is given until you are ready to take the pill form of tacrolimus. • Take oral tacrolimus at the same time each day, with a full glass of water. • Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions. • Swallow the tablet or capsule whole and do not crush, chew, break, or open it. • Tacrolimus oral granules must be mixed with water right before you take them. Do not save this mixture for later use. Do not get the oral granule powder or mixture on your skin or in your eyes. If this happens, wash your skin with soap and water or rinse your eyes with water. • Take Astragraf XL or Envarsus XR in the morning on an empty stomach, at least 1 hour before or • 2 hours after a meal. • You may take Prograf with or without food, but take it the same way each time. Source : https://www.drugs.com/mtm/tacrolimus-oral-and-injection.html

4. What happens if I miss a dose? • For Prograf: Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. • For Astragraf XL: Take the medicine as soon as you can, but skip the missed dose if you are more than 14 hours late for the dose. • What happens if I overdose? • Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. • What should I avoid while taking TACROLIMUS? • Do not receive a live vaccine while using tacrolimus, or you could develop a serious infection. Live vaccines include measles, mumps, rubella (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine. • Grapefruit may interact with tacrolimus and lead to unwanted side effects. Avoid the use of • grapefruit products. Source :https://www.drugs.com/mtm/tacrolimus-oral-and-injection.html

5. TACROLIMUS • Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. • You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as: fever, chills, flu symptoms, cough, sweating, painful skin sores, skin warmth or redness, or muscle aches. • Also call your doctor at once if you have: • general ill feeling, pain or swelling near your transplanted organ; • headaches, vision changes, pounding in your neck or ears; • confusion, behavior changes; • a seizure; • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out); • chest pain, cough, trouble breathing (even while lying down). Source : https://www.drugs.com/mtm/tacrolimus-oral-and-injection.html

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