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2. What is RIBOCICLIB? • Ribociclib is used to treat hormone-related breast cancer in women. Ribociclib is used only if your cancer tests negative for a protein called human epidermal growth factor receptor 2 (HER2). HER2 protein can speed the growth of cancer cells. • Ribociclib is used when the cancer has progressed or has spread to other parts of the body after other treatments. • Ribociclib is given in combination with another cancer medicine such as letrozole (Femara) or fulvestrant (Faslodex). • Ribociclib may also be used for purposes not listed in this medication guide. • Warnings • Ribociclib can cause serious side effects on your heart, liver, or lungs. Call your doctor at once if you have chest pain, fast or pounding heartbeats, trouble breathing, cough (with or without mucus), sudden dizziness, right-sided upper stomach pain, loss of appetite, unusual bleeding or bruising, dark urine, or yellowing of your skin or eyes. Source : https://www.drugs.com/mtm/ribociclib.html

3. How should I take RIBOCICLIB? • Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed. • Ribociclib is given in a 28-day treatment cycle. You will take the medicine for the first 21 days of each cycle, followed by 7 days off. Your doctor will determine how long to treat you with ribociclib. • Swallow the tablet whole and do not crush, chew, or break it. • Take the medicine at the same time each morning, with or without food. • If you vomit after taking the medicine, wait until the next day to take your next dose. • Do not use a broken or damaged pill. • You may need frequent medical tests to be sure ribociclib is not causing harmful effects. Your cancer treatments may be delayed based on the results. • Store ribociclib in the original container at room temperature, away from moisture and heat. Source : https://www.drugs.com/mtm/ribociclib.html

4. What happens if I miss a dose? • Skip the missed dose. Take your next dose at the regular time and stay on your once-daily schedule. Do not use 2 doses in one day. • What happens if I overdose? • Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. • What should I avoid while taking RIBOCICLIB? • Grapefruit may interact with ribociclib and lead to unwanted side effects. Avoid the use of grapefruit products. • Avoid taking an herbal supplement containing St. John's wort at the same time you are taking ribociclib. Source :https://www.drugs.com/mtm/ribociclib.html

5. RIBOCICLIB • Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). • Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. • Call your doctor at once if you have: • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out); • low white blood cell counts--fever, mouth sores, skin sores, sore throat, cough, trouble breathing; • signs of inflammation in the lungs--new or worsening cough, painful or difficult breathing, wheezing, feeling short of breath even while resting; or • liver problems--loss of appetite, upper stomach pain, tiredness, easy bruising or bleeding, dark urine, jaundice (yellowing of the skin or eyes). Source : https://www.drugs.com/mtm/ribociclib.html

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