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Yuli Lestari 10505002

Ubiquitin- Protein Ligase Tambahan pembahasan Artikel : Getting into position : the catalytic mechanisms of protein ubiquitylation. Yuli Lestari 10505002. Agenda Presentasi. Overview Ubiquitin, Ubiquitin Ligase Artikel Pendahuluan Pengaruh Modifikasi Ubiquitin

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Yuli Lestari 10505002

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  1. Ubiquitin- Protein LigaseTambahan pembahasanArtikel :Getting into position : the catalytic mechanisms of protein ubiquitylation Yuli Lestari 10505002

  2. Agenda Presentasi • Overview Ubiquitin, Ubiquitin Ligase • Artikel • Pendahuluan • Pengaruh Modifikasi Ubiquitin • The Ubiquitin-Proteosom Pathway • Mekanisme Katalitik

  3. Overview… • Sejarah • 1975 pertama kali diidentifikasi • Ditemukan berat molekul • Belum diketahui fungsi secara umum • Perkembangan Penelitian • Isolasi • Pemurnian • Karakterisasi

  4. Overview…(2) • Definisi • Ubiquitin • Ubiquitin Ligase (6.3.2.19) • Struktur

  5. Overview…(3) • Peran Ubiquitin Ligase • Ubiquitilation system

  6. Overview…(4) • Peran Ubiquitin Ligase • Proses Antigen • Apoptosis • Biogenesis organel • Siklus sel • Transkipsi DNA • Diferensiasi • Respon immun dan imflamasi • Infeksi virus • Biogenesis ribosom, dan lain-lain.

  7. Overview…(4) • Domain Ubiquitin Ligase

  8. Artikel… • Judul: Getting into position : the catalytic mechanisms of protein ubiquitylation *Lori A Passmore dan David Barford *Section of structural Biology, The Insitut of Cancer Research, Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK

  9. Artikel…(2) • Pendahuluan • Latar Belakang • Tujuan

  10. Artikel…(3) • Pengaruh Modifikasi Ubiquitin

  11. Artikel…(4) • The Ubiquitin-Proteosom Pathway

  12. Artikel…(5) • Mekanisme Katalitik • E1, enzim ubiquitin pengaktifasi Reaksi yang terjadi: ATP+ubiquitin+lysine ↔AMP+diphosphate+protein N-ubiquityllysine • E2, enzim ubiquitin terkonjugasi Pada tahap ini, terjadi proses transfer ubiquitin.

  13. Artikel…(6) • Mekanisme Katalitik Proses Transfer:

  14. Artikel…(7) • Mekanisme Katalitik • E3, Ubiquitin Ligase • E3 HECT Ubiquitin Ligase • E3 RING Ubiquitin Ligase

  15. Artikel…(8) • E3 HECT Ubiquitin Ligase

  16. Artikel…(9) • E3 RING Ubiquitin Ligase

  17. Artikel…(10) • Reaksi Katalisa Ubiquitin dan Asetilasi

  18. Sekian… Wassalamualaikum…

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