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Narcolepsy. Jerry Fang. What is Narcolepsy?. Chronic neurological disorder Not very well understood and much still remains a mystery Chracterized by: Severe fatigue Irresistible episodes of sleep General sleep disorder. Symptoms of Narcolepsy. Excessive Daytime Sleepiness

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narcolepsy

Narcolepsy

Jerry Fang

what is narcolepsy
What is Narcolepsy?
  • Chronic neurological disorder
  • Not very well understood and much still remains a mystery
  • Chracterized by:
    • Severe fatigue
    • Irresistible episodes of sleep
    • General sleep disorder
symptoms of narcolepsy
Symptoms of Narcolepsy
  • Excessive Daytime Sleepiness
  • Prolonged drowsiness
  • Cataplexy- skeletal muscles paralyzed
  • Sleep paralysis- inability to talk or move
  • Hynagogic hallucinations- vivid dreams
  • Automatic behavior- no memory of behavior
essentially narcolepsy
Essentially, Narcolepsy…
  • Is believed to be a disregulation of the sleep cycle
  • Symptoms can be explained if REM occurs very early
  • Supported by patient diagnoses
diagnoses
Diagnoses
  • 3 million worldwide
  • 200,000 in US, only 50,000 diagnosed
  • Average of 15 years to properly diagnose
  • 2 Treatments
    • Polysomnogram
      • Brain waves
      • Eye movements
      • Muscle activity
      • Heart rhythm
      • Respiratory efforts
    • Multiple sleep latency tests
      • Brain waves
causes of narcolepsy
Causes of Narcolepsy
  • Mechanism is not known
  • Has a Genetic Basis, (8-12%)
  • Orexin (hypocretin) involved
  • Orexin Receptors involved
  • Might be autoimmune (HLA complex w/ Orexin)
research
Research
  • Improved methods to diagnose and treat
  • Genetic and Environmental Linkage
  • Mechanism of Action
    • Immunological
    • Biochemical
    • Physiological
    • Neuromuscular
  • Animals
treatments
Treatments
  • Lifestyle Changes
  • Drugs
    • Only treat symptoms
    • No treatment for underlying
  • Support Groups
reference
Reference
  • "Life After Dark: the Secret World of Sleep." East Jefferson General Hospital. 20 Apr. 2006 <http://www.eastjeffhospital.org/membership/healthylifestyles/articles/lifeafterdark.html>.
  • "Narcolepsy." Wikipedia. 18 Apr. 2006. 18 Apr. 2006 <http://en.wikipedia.org/wiki/Narcolepsy>.
  • S, J M. "The Neural Circuitry of Narcolepsy." Sleep Research. UCLA. 20 Apr. 2006 <http://www.npi.ucla.edu/sleepresearch/0100siegelbox1.html>.
  • Lin, Ling, and Emmanuel Mignot. "The Sleep Disorder Canine Narcolepsy is Caused by a Mutation in the Hypocretin Receptor 2 Gene." Cell 98 (1999): 365-376.
  • Chemelli, Richard M., and Masashi Tanagisawa. "Narcolepsy in Orexin Knockout Mics: Molecular Genetics of Sleep Regulation." Cell 98 (1999): 437-451.
  • Wood, Debra. "In His Own Words: Living with Narcolepsy." Feb. 2002. Aurora Health Care. 20 Apr. 2006 <http://www.aurorahealthcare.org/yourhealth/healthgate/getcontent.asp?URLhealthgate=%229662.html>
  • Larson, Heather, Gina Kemp, and Robert Segal. "Narcolepsy: Symptoms, Causes, Diagnosis and Treatment." Helpguide. 09 May 2005. 18 Apr. 2006 <http://www.helpguide.org/life/narcolepsy_symptom_causes_treatments.htm>.
  • Takai, Tomoto, Takao Takaya, and Takahisa Ikegami. "Orexin-a is Composed of a Highly Conserved C-Terminal and a Specific, Hydrophyilic N-Terminal Region, Revealing the Structural Basis of Specific Recognition by the Orexin-1 Receptor." Journal of Peptide Science (2006). 18 Apr. 2006 <www.interscience.wiley.com>.
  • "Orexin." Wikipedia. 18 Apr. 2006. 18 Apr. 2006 <http://en.wikipedia.org/wiki/Orexin>.