2003.2 LT

1. Supplemental Digital Content 1 - Figure 1. Serum phosphate and alkaline phosphatase levels in the patients with hypophosphatemic osteomalacia before and after hospitalization. Figures A, B and C represent the clinical courses of Patients 1, 2 and 3, respectively. Filled circles with solid lines in the graphs show the levels of serum phosphate and open squares with broken lines show the levels of serum alkaline phosphatase. The striped boxes indicate periods of hospitalization for each patient. The gray zones in the graphs correspond to the normal serum phosphate level. Arrowheads show the time of liver transplantation (LT). 1 mg/day Tacrolimus 2 mg/day Fig 1A Adefovir 10 mg/day Entecavir 1 mg/day Lamivudine 100 mg/day Alphacarcidol 0.5 μg/day 2003.2 LT Bone pain P P (mg/dL) ALP (U/L) ALP 1 2 3 4 5 2 4 6 8 Years after LT Months after hospitalization Hospitalization

2. Supplemental Fig. 1B 1.5 mg/day 1 mg/day Tacrolimus 2 mg/day Adefovir dipivoxil 10 mg/day Lamivudine 100 mg/day Alphacarcidol 0.5 μg/day Phosphate 1 mg/day 2002.7 LT Bone pain ALP (U/L) P (mg/dL) P ALP 2 3 4 5 6 1 2 3 4 Years after LT Months after hospitalization Hospitalization

3. Supplemental Fig. 1C Tacrolimus 2 mg/day Prednisolone 5 mg/day Alphacarcidol 2 μg/day 2001.7 LT Bone pain P P (mg/dL) ALP (U/L) ALP 3 4 5 6 7 1 2 3 4 5 6 7 8 Years after LT Months after hospitalization Hospitalization