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Peptide Pheromone Control in Streptococcus spp: A Model Approach

Explore the intriguing mechanism of how a double-tryptophan peptide pheromone regulates competence in Streptococcus spp. through the Rgg regulator. Discover the critical role of Rgg2 and Rgg3 in controlling biofilm development in Group A Streptococcal strains. This innovative model sheds light on complex signaling pathways in bacterial competence and biofilm formation.

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Peptide Pheromone Control in Streptococcus spp: A Model Approach

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  1. 4 Rggs in GAS

  2. Competence Model Mashburn-Warren, L.et al. 2010. A novel double-tryptophan peptide pheromone controls competence in Streptococcus spp. via an Rgg regulator.Mol Microbiol, 78(3):589-606. PMID: 20969646.

  3. Model for Rgg2 and Rgg3 Chang, J.C. et al. Two Group A Streptococcal Peptide Pheromones Act Through Opposing Rgg Regulators to Control Biofilm Development. PLoSPathog. 7(8): e1002190. doi:10.1371/journal.ppat.1002190.

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