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Environmental Occurrence POPs in Environmental and Human samples

Environmental Occurrence POPs in Environmental and Human samples. Takeshi NAKANO. ( Hyogo Pref. Inst. of Env. Sci.). ntakeshi @ elis.pref.hyogo.jp. ２３４７８－ PeCDF. ２３７８－ TCDD. ７５. １３５. ７５. ２０９. １２３５６７－ HxCN. ３４５３’４’－ Co-PCB. PCB issue in Japan. PCB in Japan ca 60,000t.

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Environmental Occurrence POPs in Environmental and Human samples

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  1. Environmental Occurrence POPs in Environmental and Human samples Takeshi NAKANO (Hyogo Pref. Inst. of Env. Sci.) ntakeshi@elis.pref.hyogo.jp

  2. ２３４７８－PeCDF ２３７８－TCDD ７５ １３５ ７５ ２０９ １２３５６７－HxCN ３４５３’４’－Co-PCB

  3. PCB issue in Japan

  4. PCB in Japan ca 60,000t National Project in 1985-1989 Decomposition in Takasago, Hyogo pref. Liquid-PCB 5,500t 90% of PCB still remain in Environment

  5. TEQ Level of technical PCB

  6. PCB concentration and TEQ value KC300 KC400 KC500 KC600 0.7ｘ１０－５ ２ｘ１０－５ ６ｘ１０－５ ３ｘ１０－５ pg-TEQ/g 0.7ｘ１０7 2 ｘ１０7 6 ｘ１０7 3 ｘ１０7

  7. 90% of PCB still remain in Environment PCB • Transformer (Japan Railway, Power company ) • Carbon free Paper(Non Carbon Paper) • Sealant PCB (old building during 1968-72) • Fluorescent lamp stabilizer (old type) • etc

  8. PCB Homologue Distribution and Source Estimation

  9. Source estimation KC３００ KC５００ Insulator N.C.P. capacitor Sediment A Sediment B KC４００ KC６００ Ship paint Insulator capacitor

  10. Isomer distribution and Source estimation Sediment A Water A KC300

  11. Isomer distribution and Source estimation KC４00 KC５00 KC６00

  12. PCB contamination in Sea sediment

  13. Thermal 熱安定性 PCBは汚染拡散の重要な指標 PCB: important index for Pollutant dispersion 化学的 chemical 環境中で分解しない。：難分解性 Stable in environment : persistent 生物学的 biological 使用期間10～20年の環境負荷 Environmental loading : 10-20 years 209 congeners : much information 異性体 209 ： 情報量が多い 海域底質中PCBの鉛直分布 Vertical distribution of PCB in sediment core PCB汚染の時間的・経年変化 Historical trend of PCB pollution 海域底質中PCBの水平分布 Horizontal distribution of PCB in sediment PCB汚染の空間的移動 Spatial migration of PCB

  14. Vertical distribution of PCB in sea sediment

  15. Production of N.C.P PCB concentration Sediment core Annual production Annual production and Vertical distribution in sediment

  16. Horizontal distribution of PCB in sea sediment

  17. Horizontal distribution in sea sediment 播磨灘 Harima nada 大阪湾 Osaka Bay Independent area western and eastern part スープ皿のような地形 東半分：陸、西半分：海 like a soup dish Sea bottom and water depth 海底の地形・水深

  18. Horizontal distribution in sea sediment Channel : fast stream sand silt silt sand Central part: slow stream Particle size in sea sediment

  19. 海域底質の粒度分布を考慮しない場合 Before normalization by particle size distribution coast High Inmost part High Low channel High 濃度の単調減少 Harima nada Low 鳴門 Osaka Bay Central part : High Horizontal distribution in sea sediment

  20. 海域底質の粒度分布を考慮した場合 After normalization by particle size distribution Constant flow map and PCB distribution 恒流図と濃度分布 粒径・微細粒子・比表面積で規格化 海域底質中PCBの水平分布 Horizontal distribution in sea sediment

  21. Horizontal distribution in sea sediment 海域底質の水平分布 神戸港周辺 Around Kobe port Osaka bay 大阪湾 PCB濃度の距離減衰 PCB concentration and Distance from source

  22. PCB congener profile in Environmental and Human samples

  23. HW1013+KC3-600 357936 Intensity 0 14 15 16 17 18 19 Retention Time (min) Isomer distribution（TeCB） PCB product sediment 01Sed-55 68784 Intensity 0 14 15 16 17 18 19 Retention Time (min) seawater Portisland7/19-6L 20656 Intensity 1000 14 15 16 17 18 19 human milk MM-44 14512 Intensity 952 14 15 16 17 18 19 adipose tissue o-neck-fat 41200 Intensity 0 14 15 16 17 18 19 #74(2,4,4',5-)

  24. HW1013+KC3-600 122592 Intensity 0 16 17 18 19 20 21 22 Retention Time (min) Isomer distribution （PeCB） PCB product sediment 01Sed-55 33272 Intensity 0 16 17 18 19 20 21 22 Retention Time (min) seawater Portisland7/19-6L 8520 Intensity 984 16 17 18 19 20 21 22 human milk MM-44 22336 Intensity 0 16 17 18 19 20 21 22 adipose tissue o-neck-fat 19448 Intensity 992 16 17 18 19 20 21 22 #118(2,3’,4,4',5-) #99(2,2’,4,4',5-)

  25. HW1013+KC3-600 124328 Intensity 0 18 19 20 21 22 23 24 Retention Time (min) 01Sed-55 32392 Intensity 0 18 19 20 21 22 23 24 Retention Time (min) Isomer distribution （HxCB） PCB product sediment seawater Portisland7/19-6L 5128 Intensity 992 18 19 20 21 22 23 24 human milk MM-44 47792 Intensity 0 18 19 20 21 22 23 24 adipose tissue o-neck-fat 162432 Intensity 0 18 19 20 21 22 23 24 #153(2,2',4,4',5,5'-) #138(2,2',3,4,4',5'-)

  26. HW1013+KC3-600 74056 Intensity 0 20.0 20.5 21.0 21.5 22.0 22.5 23.0 23.5 24.0 24.5 25.0 25.5 Retention Time (min) 01Sed-55 8744 Intensity 960 20.0 20.5 21.0 21.5 22.0 22.5 23.0 23.5 24.0 24.5 25.0 25.5 Retention Time (min) 20.0 20.5 21.0 21.5 22.0 22.5 Isomer distribution （HpCB） PCB product sediment seawater Portisland7/19-6L 2080 Intensity 984 23.0 23.5 24.0 24.5 25.0 25.5 human milk MM-44 16312 Intensity 944 20.0 20.5 21.0 21.5 22.0 22.5 23.0 23.5 24.0 24.5 25.0 25.5 Retention Time (min) adipose tissue o-neck-fat 42888 Intensity 0 20.0 20.5 21.0 21.5 22.0 22.5 23.0 23.5 24.0 24.5 25.0 25.5 Retention Time (min) #187 #180 #170

  27. human milk/adipose tissue #153 (2,2',4,4',5,5'-) #74 (2,4,4',5-) #138 (2,2',3,4,4',5'-) #99(2,2’,4,4',5-) #187 (2,2',3,4’,5,5’,6-) #118 (2,3’,4,4',5-)

  28. CYP1A,CYP2A 4-OH CYP2B 3-OH

  29. C l C l C l C l C l C l # 1 5 3 ( 2 , 4 , 5 , 2 ' , 4 ' , 5 ' ) PCB#153　代謝 ヒトラットハムスターサル イヌモルモット H O C l C l > C l C l C l C l > d o g ( C Y P 2 B 1 1 ) h u m a n ( C Y P 2 B 6 ) g u i n e a p i g ( C Y P 2 B 1 8 ) r a t , h a m s t e r

  30. POPs in Human Breast Milk

  31. POPs in Human Breast Milk ng/g-fat

  32. PCBs in Human Breast Milk ng/g-fat

  33. PCB in Water and Mussel

  34. Polychlorinated biphenyl(PCB) is well-known environmental pollutants. In Japan, approximately 58,000t of PCB was produced and imported from overseas by 1972 . Despite of the ban and restriction of PCB usage since 1972, 90% of total products has still been untreated. • PCB is transported in the environment(water, air, and ecosystem) in various forms.

  35. Sampling Points Himeji Kako River Muko River Yodo River Akashi Port Island Nanko Hokutan Izumiotsu Yura Around Harima-nada and Osaka Bay, this investigation have been done once a month from May, 2001 to Aug, 2001

  36. PCB productionWorld : 1,200,000t Japan : 59,000t Harima-nadaOsaka-Bay Japan Osaka 1962-1971 Hyogo Kinki 1962-1971

  37. Level 10 ng/g-dry 100 ng/g-dry Harima-nada Osaka-Bay PCB in sea sediment

  38. average Harima-nada Osaka-Bay Harima-nada Osaka-Bay 80 ng/g 5 ng/L 1 ng/L 35 ng/g-wet Sea Water Mussel The range of total PCBs concentration (May,2001~July,2001)

  39. average Harima-nada Osaka-Bay Harima-nada Osaka-Bay 5 ng/g 2 ng/g-wet 0.06 ng/L 0.3 ng/L Sea Water Mussel The range of total co-PCBs concentration (May,2001~July,2001)

  40. Sea Water Mussel Fig #11/ΣDiCBｓ in June, 2001

  41. #180 #174 #170 KC300-600 Intensity Sea Water Mussel Isomer distribution (P7CB, Port Island in June,2001)

  42. KC300-600 Intensity Sea Water Mussel #196#203 #195 #194 #199 #202 #201 Isomer distribution (O8CB, Port Island in June, 2001)

  43. P2CB P3CB P4CB P5CB P6CB P7CB P8CB Sea Water Mussel Homologue Distribution in June,2001

  44. PCB #11 New Source

  45. ＃11 4,4‘-Diamino-3,3’-dichlorobiphenyl

  46. PCN TEQ Level in Ambient Air

  47. Atmospheric PCN (pg-TEQ/m3) in Japan (JEPA) 1 0.1 0.01 0.001 0.0001 0.00001 0 1 2 3 4 5 6 7 8 9 10

  48. TEQ contribution of PCDD/PCDF/PCB/PCN in Ambient Air

  49. Ambient air (pg-TEQ/m3) Ambient air (pg/m3) Total concentration TEQ concentration Atmospheric level of PCB/PCN/PCDD/PCDF

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