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    2. Drug Induced Liver Injury Network DILIN Cooperative Agreement

    5. DILIN: Sphere of Influence

    8. DILIN First Phase working definitions for drug-induced liver toxicity, diagnostic algorithms, causality assessment protocol or instrument, study design to identify cases, manual of operations for clinical data & specimen collection, and patient consent form. Second Phase implement operating procedures, enroll patients and control subjects, capture data and samples (serum, tissue, DNA).

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    10. Protocol #1: ILIAD specific aims 1.   To establish and maintain a clinical database on patients who have suffered severe idiosyncratic DILI. 2. Establish a bank of biological specimens (serum, DNA, and immortalized lymphocytes) prepared from cases and suitable controls.

    11. ILIAD specific aims, con’t 3). Maintain a registry, including yearly updated contact information of the subjects enrolled in the clinical database so that it is possible to recontact these individuals at a later date to offer participation in phenotype/genotype studies.

    12. Considerations for target drugs for ILIAD

    13. Drugs Targeted (target n= 50-100 / drug) 1). INH 2). valproate 3). phenytoin 4). amoxacillin/clavulanic acid

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