Role of SHARPIN and HOIL-1L in IKK and NF-κB Activation

May 17, 2025

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This study explores the essential role of SHARPIN and HOIL-1L in the full activation of IKK and NF-κB signaling pathways. The research, published in Nature, sheds light on the molecular mechanisms underlying immune responses and inflammation.

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Role of SHARPIN and HOIL-1L in IKK and NF-κB Activation

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SHARPIN and HOIL-1L are essential for full activation of IKK and NF-B. F Ikeda et al.Nature471, 637-641 (2011) doi:10.1038/nature09814

Z-X Luo et al. Nature 476 , 442-445 (2011) doi:10.1038/nature10291

Time-calibrated phylogeny of the eutherian Juramaia among other boreosphenidan mammals, and comparative morphology of some key molar features. Z-X Luo et al. Nature 476 , 442-445 (2011) doi:10.1038/nature10291.

141 views • 1 slides

K Hada et al . Nature 477 , 185-187 (2011) doi:10.1038/nature10387

VLBA image of M87 at 43 GHz superimposed on the measured core-shift positions. K Hada et al . Nature 477 , 185-187 (2011) doi:10.1038/nature10387.

122 views • 1 slides

Z-X Luo et al. Nature 476 , 442-445 (2011) doi:10.1038/nature10291

Dental and mandibular features of Juramaia sinensis (BMNH PM1343B). Z-X Luo et al. Nature 476 , 442-445 (2011) doi:10.1038/nature10291.

176 views • 1 slides

M Pellegrino et al. Nature 000 , 1-4 (2011) doi:10.1038/nature10438

OR59B–ORCO sensitivity to DEET varies across wild-type D. melanogaster strains. M Pellegrino et al. Nature 000 , 1-4 (2011) doi:10.1038/nature10438.

183 views • 1 slides

M Taniguchi-Ikeda et al. Nature 478 , 127 - 131 (2011) doi:10.1038/nature10456

An SVA retrotransposal insertion induces abnormal splicing in FCMD. M Taniguchi-Ikeda et al. Nature 478 , 127 - 131 (2011) doi:10.1038/nature10456.

103 views • 1 slides

F Maillet et al. Nature 469 , 58-63 (2011) doi:10.1038/nature09622

Synthetic Myc-LCOs stimulate M. truncatula root branching by the DMI pathway. F Maillet et al. Nature 469 , 58-63 (2011) doi:10.1038/nature09622.

118 views • 1 slides

S Ruediger et al . Nature 000 , 1 - 5 (2011) doi:10.1038/nature09946

Critical role of mossy fibre Add2 for feedforward inhibition growth at LMTs and hippocampal memory precision. S Ruediger et al . Nature 000 , 1 - 5 (2011) doi:10.1038/nature09946.

130 views • 1 slides

J She et al . Nature 000 , 1 - 5 (2011) doi:10.1038/nature10178

Brassinolide binds a hydrophobic groove between the insertion domain and the inner surface of LRRs. J She et al . Nature 000 , 1 - 5 (2011) doi:10.1038/nature10178.

156 views • 1 slides

H Minemawari et al. Nature 000 , 1-4 (2011) doi:10.1038/nature10313

Transistor characteristics for the inkjet-printed C 8 -BTBT single-crystal thin films. H Minemawari et al. Nature 000 , 1-4 (2011) doi:10.1038/nature10313.

124 views • 1 slides

SL Morford et al . Nature 477 , 78-81 (2011) doi:10.1038/nature10415

Total nitrogen in rock, soil and foliage pools for SFM and BWDC forests. SL Morford et al . Nature 477 , 78-81 (2011) doi:10.1038/nature10415.

106 views • 1 slides

S Naoz et al. Nature 473 , 187-189 (2011) doi:10.1038/nature10076

Dynamical evolution of a representative two-planet system with tidal dissipation included. S Naoz et al. Nature 473 , 187-189 (2011) doi:10.1038/nature10076.

92 views • 1 slides

F Lederbogen et al. Nature 474 , 498-501 (2011) doi:10.1038/nature10190

Relationship between early life urbanicity scores and pACC activation. F Lederbogen et al. Nature 474 , 498-501 (2011) doi:10.1038/nature10190.

168 views • 1 slides

LE Sander et al . Nature 000 , 1 -5 (2011) doi:10.1038/nature10072

Bacterial RNA is a vita-PAMP that accesses cytosolic receptors during phagocytosis and in the absence of virulence factors. LE Sander et al . Nature 000 , 1 -5 (2011) doi:10.1038/nature10072.

94 views • 1 slides

YZ Pei et al. Nature 473 , 66 -69 (2011) doi:10.1038/nature09996

Temperature dependence of the zT of p-PbTe 1  x Se x materials doped with 2 atom % Na. YZ Pei et al. Nature 473 , 66 -69 (2011) doi:10.1038/nature09996.

187 views • 1 slides

F-Y Li et al. Nature 475 , 471 - 476 (2011) doi:10.1038/nature10246

MAGT1 deficiency impairs PLC c  1 activation upon TCR stimulation. F-Y Li et al. Nature 475 , 471 - 476 (2011) doi:10.1038/nature10246.

121 views • 1 slides

DJ Gibbs et al . Nature 000 , 1 - 4 (2011) doi:10.1038/nature10534

Group VII ERF transcription factors are substrates for the N-end rule pathway in vitro and in vivo. DJ Gibbs et al . Nature 000 , 1 - 4 (2011) doi:10.1038/nature10534.

135 views • 1 slides

BO Schroeder et al. Nature 469 , 419-423 (2011) doi:10.1038/nature09674

Thioredoxin (TRX) catalyses reduction of oxidized hBD-1 and co-localizes with redhBD-1 in vivo. BO Schroeder et al. Nature 469 , 419-423 (2011) doi:10.1038/nature09674.

114 views • 1 slides

BA Zauderer et al. Nature 476 , 425-428 (2011) doi:10.1038/nature10366

SEDs (luminosity,  L  ; frequency,  ) of Swift J164449.3+573451 from radio to X-rays point to synchrotron emission from a relativistic outflow. BA Zauderer et al. Nature 476 , 425-428 (2011) doi:10.1038/nature10366.

103 views • 1 slides

KJ Brennand et al . Nature 000 , 1 - 5 (2011) doi:10.1038/nature09915

Decreased neurites and synaptic protein levels but normal electrophysiological and spontaneous calcium transient activity in SCZD hiPSC neurons. KJ Brennand et al . Nature 000 , 1 - 5 (2011) doi:10.1038/nature09915.

122 views • 1 slides

KM Esvelt et al . Nature 000 , 1 - 5 (2011) doi:10.1038/nature09 929

Linkage of three protein activities to pIII production and phage infectivity using three distinct accessory plasmids. KM Esvelt et al . Nature 000 , 1 - 5 (2011) doi:10.1038/nature09 929.

142 views • 1 slides

FG Jiang et al . Nature 000 , 1 - 5 (2011) doi:10.1038/nature10537

Limited trypsin digestion, DSF and SAXS analyses of helicase-RD and full-length RIG-I in the presence and absence of dsRNA. FG Jiang et al . Nature 000 , 1 - 5 (2011) doi:10.1038/nature10537.

111 views • 1 slides

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