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UniProtKB/Swiss-Prot - PowerPoint PPT Presentation

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The UniProt Consortium

The UniProt Consortium is a collaboration between the Swiss Institute of Bioinformatics (SIB), the European Bioinformatics Institute (EBI), and the Protein Information Resource (PIR) in USA. Across the three institutes, close to two hundred people are involved in database curation, software development, user support, and education.

Until a few years ago, EBI and SIB together produced Swiss-Prot and TrEMBL, while PIR produced the Protein Sequence Database (PIR-PSD). These two data sets coexisted with different protein sequence coverage and annotation priorities.

TrEMBL (Translated EMBL Nucleotide Sequence Data Library) was originally created because sequence data was being generated at a pace that exceeded Swiss-Prot annotation ability. Meanwhile, PIR maintained the PIR-PSD and related databases, including iProClass, a database of protein sequences and curated families.

In 2002, the three institutes decided to pool their resources and expertise and created the UniProt Consortium.

The UniProt Consortium produces the Universal Protein Resource (UniProt), which provides a central resource on protein sequences and functional annotation with three database components (UniProtKB, UniRef, UniPArc), each addressing a different key need in protein bioinformatics research.

UniProt Consortium






and more…


and more…

The Universal Protein Resource

1. The UniProt Knowledgebase

UniProtKB = UniProtKB/SwissProt+UniProtKB/TrEMBL

2. The UniProt Reference Cluster (UniRef)

3. The UniProt Archive (UniParc)


and more…


UniProt is mainly supported by the National Institutes of Health (NIH) grant 2 U01 HG02712-04. Additional support for the EBI's involvement in UniProt comes from the European Commission contract FELICS (021902) and from the NIH grant 5 P41 HG02273-06. UniProtKB/Swiss-Prot activities at the SIB are supported by the Swiss Federal Government through the Federal Office of Education and Science. PIR activities are also supported by the NIH grants for NIAID proteomic resource (HHSN266200400061C) and grid enablement (NCI-caBIG-ICR), and National Science Foundation grants for protein ontology (ITR-0205470) and BioTagger (IIS-0430743).