igor sharakhov n.
Download
Skip this Video
Loading SlideShow in 5 Seconds..
Igor Sharakhov PowerPoint Presentation
Download Presentation
Igor Sharakhov

Loading in 2 Seconds...

play fullscreen
1 / 15

Igor Sharakhov - PowerPoint PPT Presentation


  • 159 Views
  • Uploaded on

Igor Sharakhov. High Rates of Genome Rearrangements in Malaria Mosquitoes, Anopheles gambiae and A. funestus. University of Notre Dame, USA. Genus Anopheles Subgenus Cellia. Series Pyretophorus gambiae species complex. Myzomyia funestus group. A. gambiae. A. funestus.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Igor Sharakhov' - palmer


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
igor sharakhov
Igor Sharakhov

High Rates of Genome Rearrangements in Malaria Mosquitoes, Anopheles gambiae and

A. funestus

University of Notre Dame, USA

slide2

GenusAnopheles

Subgenus Cellia

  • Series Pyretophorus
  • gambiae species complex
  • Myzomyia
  • funestus group

A. gambiae

A. funestus

slide3

FISH on chromosomes of A. funestus

Of 157 cDNAs used as probes, 116 mapped to single chromosomal locations, and the remainder hybridized in multiple locations

slide5

Synteny at the whole arm level

  • Reciprocal whole arm translocation between 2L and 3R
slide6

Gene order comparison

  • funestus
  • A. gambiae

Length of X – 24.9Mb

Mean length of conserved segments - 2.0Mb0.2Mb

Number of inversions - 51

(Nadeau &Taylor, PNASUSA. 1984 Feb;81(3):814-8 )

slide7

funestus

  • A. gambiae

Mean length of conserved segments - 0.9Mb0.2Mb

Number of inversions - 369

  • funestus
  • A. gambiae

Mean length of conserved segments - 2.2Mb1.0Mb

Number of inversions - 113

slide8

funestus

  • A. gambiae

Mean length of conserved segments - 2.2Mb0.4Mb

Number of inversions - 113

  • funestus
  • A. gambiae

Mean length of conserved segments - 1.1Mb0.4Mb

Number of inversions - 195

slide9

Rate of gene order rearrangement

The divergence time between A. gambiae

and A. funestus lineages is ~ 5 My

slide12

Attachments of chromosomes to

the nuclear envelope (NE)

A. funestus

A. gambiae

(Sharakhov et al. Genetics. 2001 Sep;159(1):211-8)

slide13

Function of nuclear organization in

interphase chromosome interactions

(Marshall WF, Curr Biol. 2002 Mar 5;12(5):R185-92)

conclusions
Conclusions
  • Gene order has being shuffled at a high rate
  • Paracentric inversions have had a major impact on the genome rearrangement
  • Genomic segments evolve at different rates
slide15

University of Notre Dame, USA

  • Andrew Serazin, Olga Grushko, Ali Dana, Neil Lobo, Maureen Hillenmeyer, Frank Collins, Nora Besansky
  • Purdue University, USA
  • Richard Westerman, Jeanne Romero-Severson
  • Centre National de Recherche et de Formation sur le Paludisme, Burkina Faso
  • N’Fale Sagnon, Carlo Costantini

This work was supported by grants from the National Institutes of Health (AI48842) to N.B. and from the Indiana 21st Century Research & Technology Fund to F.C.