Pharmacology Review I

1. Pharmacology Review I Chapters 1 - 28 All Materials in this presentation come from: Karch, A. (2008). Focus on: nursing pharmacology. New York, NY: Lippincott Williams & Wilkins.

2. Mrs. Smith, a lively 78 yr old woman, successfully receiving Lasix (a diuretic) for hypertension comes in to the office…complaining of UTI symptoms. She wants to know why the doctor did not prescribe Gentamicin. “I used to always take Gentamicin”…..what do you explain to her? Case Study # 1 Antibiotics

3. Gentamicin is an aminoglycoside antibiotic…aminoglycosides and Lasix can cause severe ototoxicity Mrs. Smith, are you listening to me?

4. Case Study # 2 Antibiotics • Senator X receives a letter with a suspicious powder substance. What cephalosporin will he take for anthrax expsoure?

5. CeClor (cefaclor) 250 mg PO q8h • The Nurse warns Senator X not to go to Happy Hour, why?

6. Cephalosporins • Senator X should not consume alcohol while taking cephalosporins because of a possible disulfiram-like reaction-- • Flushing, nuasea, vomiting, chest pain, palpitations, dyspnea, blurred vision, even consulsions!

7. Case Study # 3 Antibiotics • Susan is ready to head to Florida for her Spring Break, too bad she has a UTI and is taking Cipro….. • Why?

8. Photosensitvity! • Cipro can cause a severe skin reaction when pt is exposed to sunlight or tanning beds. • Susan’s grandmother in the nursing home doesn’t see much sunlight, she just needs to avoid using NSAIDs when taking Cipro !

9. Case Study # 4 Antibiotics • Uncle Larry seems confused lately…It’s a good thing the doctor prescribed Zithromax for his upper respiratory infection….. • Why?

10. Zithromax (Azithromycin) • Half-life is 68 hours so patients only need to take it once a day….usefull for patients who have trouble remembering to take their pills.

11. Case Study # 5 Antibiotics • LaTasha calls the nurse: “my baby is allergic to the amoxicillin” • The nurse will ask, “what are her symptoms?” • LaTasha says bad diarrhea…how will you council her?

12. LaTasha and her baby • Sometimes patients may confuse side effects with allergic reactions. • Typical allergic reactions include: • Hives, rash • Difficulty breathing, respiratory arrest • Increased BP, dilated pupils, • Increased heart rate, diaphoresis

13. Amoxicillin and other penicillins • Common adverse effects include nausea, diarrhea and a furry tongue. • “A furry tongue! What are you talkin’ about?” says LaTasha… • Superinfections like yeast are very common…

14. Case Study # 6 Antibiotics • Carrie’s husband has an abscessed tooth. The dentist prescribed Clindamycin (lincosamide)… • Great wife that she is, she is bummed because she just cleaned her toilets…what side effect is she thinking of?

15. Severe pseudomembranous colitis • So what’s a little colitis? • Pseudomembranous colitis is actually another superinfection. Clindamycin may allow Clostridium difficile (C. diff) to infect the colon.

16. Ancef (cefazolin)* • Ancef is one of the cephalosporins. • Toxic to the kidneys • Monitor the patient BUN levels • No alcohol while taking Ancef If pt has an allergic rxn, give parenteral epinephrine to cause vasoconstriction and bronchodilation. *(Material from ATI prep)

17. Case Study # 7 Antibiotics • Cheryl, a young nursing student, comes to the clinic with severe acne. The doctor has prescribed tetracycline. • The nurse advises her to take the medicine on an empty stomach. • Most importantly of all, her nurse asks….. Hint!

18. Antibiotics and Oral Contraceptives • Are you taking oral contraceptives? • Several antibiotics including tetracycline, are known to lead to failure of oral contraceptives. • Cheryl needs to know to use alternative methods for birth control.

19. Case Study # 8 Antimycobacterial Antibiotics • Michael volunteers at a health clinic for refugees from other countries…He is surprised to see so many patients with T.B. • He explains the treatment lasts from 6 months to two years…why?

20. Tuberculosis Treatment • The slow growing bacteria form a mycolic acid outer coating. Isoniazid, rifampin and ethionamide are the first line of defense…. Michael also learns to say: “Su pis hace naranja” spanish for “your pee will be orange” for patients taking rifampin

21. Isoniazid (INH) • Treatment for tuberculosis • Can cause lupus and jaundice from liver toxicity • Signs of jaundice: • Yellow skin • Discolored sclerae (material from ATI prep)

22. Case Study # 9 Antiviral Agents • Nathan says he feels “like crap!” • Jennifer says, “if it’s the flu and its been less than 2 days, you should try….

23. Tamiflu (oseltamivir) • 75 - 150 mg PO b.I.d. for 5 days • Also approved for use with children

24. Case Study # 10 Antiviral agents Abreva for cold sores Relenza For the FLu Aldara for skin cancers Hepsera For Hep. B (liver damage) Acyclovir For herpes Retrovir (AZT) For HIV

25. Flu symptoms Cold sores Hepatitis B HIV Herpes Skin cancers (also genital warts) Hepsera Aldara Abreva Relenza Acyclovir Retrovir (AZT) Review antiviral agents

26. Case Study # 11Antifungals There is a fungus, among us… What common antifungal is used topically for onychomycosis ?

27. Antifungals • Lamisil is commonly used cream and is pretty safe …however… other antifungals are not used topically Why would anyone need to take pills for fungus?

28. Case Study # 12 Antifungals • Answer: Superinfections Azoles are used to treat Candidiasis, systemic fungal infecitons and to prevent candidiasis in bone marrow transplants Remember the “furry tongue” see case # 5

29. Antifungal Drug to Drug interactions Systemic antifungals like azoles may become toxic with: • digoxin • oral hypoglycemics • warfarin • phenytoin • cyclosporine Sounds like the average nursing home cocktail to me…

30. Case Study # 13Antiprotozoal agents • Michael decides to take his clinic to Africa… • What drug will he need to take to prevent malaria? • Should Michael and his wife plan to have kids while they are over there?

31. Antimalarial medication • Chloroquine (Aralen) blocks the reproduction of the plasmodium organisms. • Chloroquine has potential risk to pregancy • Also can cause serious eye damage and blindness

32. Case Study # 14 Antiprotozoals • Cindy and Tara went backpacking in the Smoky Mtns. Cindy warned Tara not to drink the water, but she did…. • Now Tara has pale, mucous filled stools and rotten egg smelling diarrhea…sounds like she needs---

33. Metroniadazole (Flagyl, MetroGel, Noritate) 750 mg PO tid for 5-10 days for amebiasis and giardiasis 2 g PO as one dose for Trichimoniasis The Travelers’ Real Friend…

34. Case Study # 15Anti-inflamatory agents • Grandpa believes “if one is good, two is better” when it comes to aspirin for his arthritis. • Lately, he complains about ringing in his ear…is there a connection?

35. Tinnitus Yes! Ringing in the ears is a classic sign of aspirin toxicity, called salicyclism. Also sweating, headache and dizziness, Granpa’s liver may not be meatbolizing the aspirin as fast as it use to ….

36. Case Study # 19Anti-inflammatory agents Brenda, an alcoholic, has had a migraine for three days. She’s been taking Tylenol extra strength whenever it starts to ache. Yesterday, she started to have flu symptoms so she’s been taking DayQuil (325 mg acetaminophen), a couple of swigs every few hours. She comes to ER with nausea, vomiting, and GI upset-- The doctor recognizes Acetaminophen Toxicity and prescribes:

37. Acetylcysteine (Mucomyst) is 100% effective in preventing liver overdose The Liver Can’t “live” Without it!

39. Gold Salts • Gold Salts are available for treatment of rheumatoid arthritis • Monitor the patient for mouth sores, GI inflamation and allergic rxns. And anaphylatic shock

40. Anaphylactic shock • Allergic rxn where body produces histmaines • Immediate swelling and constricting of bronchi Symptoms include: • urticaria (hives) • Shortness of breath • Give epinephrine Urticaria

41. Immunization schedule • Hep B • Hib • Dtap 5 - dose series (Diptheria, Tetanus,Pertussis) • IPV • MMR • PVC • Varicella

42. Anxiolytics and Hypnotic Agents • Xanax - anxiety, panic • Librium - anxiety, alcohol withdrawal • Klonopin - restless leg syndrome, panic • Valium - muscle relaxant, antiepiletptic • ProSom - hypnotic, insomnia • Ativan - anxiety, preanesthesia • Serax - preferred for elderly

43. Case Study # 20Benzodiazepines • Mr. Mason came into ER. He is a known drug abuser. He was admitted for possible stroke. • Kim, his nurse asks when was the last time he had a beer? Mr. Mason says 3 days. • Kim calls the doctor to request Ativan (STAT), why? (based on a true story)

44. Ativan (lorazepam) • Kim has seen this before…. • Mr. Mason is probably an alcoholic and will begin to have withdrawal symptoms if he stays any longer at the hospital. • Ativan will prevent wild behavior and lasts 12 - 24 hours ------------> (that will cover her shift)

45. Ativan (lorazepam) • Kim requests only 1 mg/day PO for Mr. Mason • The normal dosage is 2 -6 mg/day • Why?

46. Benzodiazepines Use lowest possible dose • Mr. Mason is an African American. • Kim knows special care needs to be taken because he may have a genetic predisposition to delayed metabolism of benzodiazepines. • She will closely monitor him for adverse effects like cardiovascular issues, urinary retention, sedation, confusion and blurred vision.

47. Benzodiazepines • Mr. Mason threatens to leave the hospital. “You can’t make me stay!” • Kim explains to him Ativan plus alcohol can cause serious CNS depression. • She flips on the movie channel and Mr. Mason calms down. Just another day for Super Nurse!

48. Barbituates • Amytal sodium - convulsions, sedative • Luminal - preanesthetic, seizures • Seconal - preanesthetic, seizures

49. Selective Serotonin Reuptake Inhibitors (SSRIs) • Luvox • Paxil • Zoloft • Celexa • Cymbalta • Prozac • Inform patients: • May take 4 weeks • To see improvement • May cause cystitis, • Urgency • sexual dysfunction • Need alternative • birth control • (If using oral contraceptives) • Do not combine • with St. John’s Wort 70 % experience Sexual dysfunction That’s depressing!

50. Case Study # 20Tricyclic Antidepressants • TCAs treat depression • Clamipramine is for OCDs • TCAs are anticholinergic so caution with: • Cardiovascular disorders • Urinary disorders • Imipramine also treats…..?