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This presentation by Sabine Beulke introduces the ModelMaker tool and its application in estimating persistence and degradation kinetics from environmental fate studies, particularly in relation to EU registration. Attendees will learn about model construction, including compartments, flows, and variables. We'll discuss the significance of DT50, initial conditions, and parameters for effective modeling of substances such as pesticides. The workshop emphasizes practical curve fitting and optimization techniques, guiding participants in creating effective graphical representations and tables for their models.
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Introduction to ModelMaker Sabine Beulke, CSL, York, UK FOCUS Work Group on Degradation Kinetics Estimating Persistence and Degradation Kinetics from Environmental Fate Studies in EU Registration Brussels, 26-27 January 2005
Model components Compartment Flow Part of the system with defined boundaries which can store the quantity of interest (e.g. a pesticide) Represents the movement of the quantity from one compartment to another Parent in soil Metabolite in soil Parent Metabolite Change of quantity in compartment with time dCompartment / dt = + Flows in - Flows out Variable Quantity which is a function of other model components or a function of an independent variable (e.g. time) DT50 as a function of other model parameters
Initial conditions and parameters For each compartment, the starting point (quantity present at the beginning of the simulation) must be defined Parent: 100% applied radioactivity Metabolite: zero Parameters are constants which do not change during the simulation kparentdegradation rate constant for the parent in soil M0 initial amount of the parent compound ffM formation fraction
ModelMaker toolbar run model optimise model create graph create table add and define parameters compartment flow variable
