IIT kharagpur as a pharmaceuticaLs consultancy

1. IIT kharagpuras a pharmaceuticaLs consultancy

2. CURRENT AREAS OF RESEARCH • Probiotics and Nutraceuticals • Microbial genetics • Antimicrobial chemotherapy • Molecular virology, Recombinant DNA technology • Structural Biology and Protein Chemistry • DNA-interacting Molecules • Enzyme Inhibitors • Structure Function of Proteins • Nucleosides as Antivirals • Biomimetic Chemistry of Metals • Computer Simulations of Biomolecules

3. RESEARCH LABORATORIES • Bio Hydrogen Lab • Bio Process Lab  • Biochemical & DSP  Lab • Cell & Molecular Biology Lab  • Micro & Immunotech Lab  • Plant Biotech Lab • Computation Lab • Medical Biotechnology Lab • Fermentation Technology Lab

4. LAB FACILITIES • Air-lift bioreactor • Atomic absorption spectrophotometer • Centrifugal evaporator • Darkroom/Cold room / Radio-isotope facilities • DNA finger printing • ELISA reader • Fermentation Technology • Gas Chromatograph • High speed refrigerated cooling centrifuge • Liquid nitrogen storage facility • Milli-Q water purifier • Netzs Thermal Analyzer (DSC, TGA, DTA) • Perkin Elmer FT IR Spectrometers • Perkin Elmer CHN Analyzer • Digital Polarimeter (JASCO) • Fluorimeter • CH Electrochemical Analyzer • Thermal Analyser • UV & Visible Spectrophotometer • Bruker AC 200 MHz NMR Spectrometer • Cyclic Voltammeter Model P9001

5. TECHNOLOGIES DEVELOPED • Magnetic Nano-Particle for Cancer Diagnostics • Extraction of Chemical from Marine Bacteria for Chemotherapy • Anti-Diabetic Drug from a Probiotic Bacterium • Bench-Scale Technology for Manufacture of Pro-Biotics • Non Invasive Sterile Drug and Device Manufacturing System • Extraction of Polyphenols from Green Tea Leaves • Smart-Reversible Inhibition of Sperm Under Guidance

6. ON-GOING PROJECTS • Technology development & transfer for selected medicinal plants: approach through R&D and ex-situ cultivation • Biosynthetic silk hydrogel extracellular matrix analogues for mammalian cell support and drug delivery • Studies on the immunomodulatory properties of Aloe vera gel and its products • Exploring the immunomodulatory potential of mushroom glucan/proteoglucan as Biological response modifier in cancer therapy • Enantiomeric separation of chiral drugs by micellarelectrokinetic capillary chromatography • A rational approach towards anticancer drugs and chemosensors

7. CONSULTANCY OFFERED • Herbal/ bioproduct development • Water pipe fermented tobacco products • Biocatalyst based continuous production of biodiesel

8. COLLABORATIONS • The UC Berkeley – IIT Kharagpur collaboration focused on biofuels (energy), and biotech (healthcare) • Indo-Norwegian- Institute collaboration onCharacterization of two histidine kinases and their cognate response regulator

9. WHY COLLABORATE WITH IIT KHARAGPUR • Research Hub • Strong intellectual capital • Produces unparalleled technically competent students • Healthy balance of core and non core engineering courses • Emphasis on hands on, learn as you do approach • Numerous successfully completed projects

10. THANK YOU

11. FEATURES • Magnetic nano-particle coated with folic acid • After injection to patient the particle is absorbed selectively by cancer cell and the lesion is easily identified by Magnetic Resonance Imaging USP • Low cost • high efficiency for detection • better than the conventional X-ray technique • Perfectly harmless to the body

12. FEATURES • Biosurfactants isolated from a marine bacterium are found to have significant antimicrobial activity and can be used in chemotherapy. • USP • Non-hemolytic in nature • Does not harm normal cell lines due to low concentration • Shows properties such as metal binding, emulsification

13. FEATURES • An exo- polysaccharide with potential anti-diabetic activity • Produced by simple fermentation and purification process • Characterized in terms of sugar monomers and its ability to reduce blood glucose levels in an animal model. USP • First anti-hyperglycemic exo-polysaccharide molecule from a pro-biotic • GRAS(Generally Regarded As Safe) by US FDA • Potential drug candidate for both type 1 and type 2 diabetes. • far better results in comparison with standard drugs for type 2 diabetes • Biodegradable, non- toxic and has no side effects

14. FEATURES • Manufacturing endospores of a pro-biotic bacterium at a lab scale • Can lead to development of some neutrateuticals • Maximum of 6 x 1012 spores/gm have been obtained • The process is optimized and stabilized in a 10 l reactor USP • Confirms to all the characteristics of a GRAS organism (US FDA) • Produced endospores can be stored under non-refrigirative condition • Very high potency and L(+) Lactic acid levels • Proven to produce bacteriocin like antimicrobial substances, antioxidant exopolysaccharides

15. FEATURES • Sterile drug or a device manufacturing system with controlled and enclosed micro-environment • All manipulations are performed by magnetic coupling across the enclosure and mini-robots placed within, controlled by electromagnetic coupling • No invasion of operating personnel; gloves; control cords into the manufacturing space USP • Cost effective (70% less than conventional clean room facility) • Minimal manufacturing zone is maintained at the best ‘Clean’ conditions • No requirement of electricity or human operator • Less particle contamination and transparency maintained by glass or polymeric sheet

16. FEATURES • Centrifugation of tea juice, followed by special membrane based filtration process and drying of concentrated liquor to produce 60-70% pure polyphenol powder • Based on water extraction - without addition of any chemicals USP • “Green Process“- absolutely safe for human consumption

17. FEATURES • Non-hormonal male injectable contraceptive in the form of a clear gel • Within an hour after injecting into the vas deferens, produces an electrical charge to nullify electrical charge of spermatozoa USP • Composition is made to be effective for more than 10 years (long lasting) • Safe with almost no side effects • Antimicrobial • Non-surgical • Cost effective