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USC Addiction and Violence Research Center. Jean C. Shih, Ph.D. School of Pharmacy University of Southern California. The First Structure of MAOB (Nat. Struc. Bol. 2002). MAO A- inhibitor interaction . MAO B Gene Regulation. Stress Inflammatory cytokines growth factors. PMA.

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USC Addiction and Violence Research Center


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usc addiction and violence research center

USC Addiction and Violence Research Center

Jean C. Shih, Ph.D.

School of Pharmacy

University of Southern California

slide4

MAO B Gene Regulation

Stress Inflammatory cytokines growth factors

PMA

Growth factors mitogens

PKC

cytoplasm

MAPK Pathway

nucleus

Egr-1

c-Jun

Sp3

Sp3 / BTEB2

TIEG2

MAO B Gene

TATA

CACCC

Sp1 / Sp4

slide5

MAO B KO mice

Wild type mice

MAO A/B double

KO mice

MAO A KO mice

slide6

Forebrain-specific transgenic MAO A KO mice

5-HT, NE, DA normal level in forebrain

No aggression

MAO B KO mice

PEA 

No aggression

MAO A/B double KO mice

5-HT, NE, DA  

PEA  

Anxiety

Disregulation of heart rate

MAO A KO mice

5-HT, NE, DA 

aggression

Different levels of 5-HT lead

to different signaling pathways

which lead to different behaviors

The increased 5-HT in forebrain

is responsible for aggression

slide7

USC Addiction and Violence Research Center

For Studying the Cause, Treatment and Prevention

of Drug Abuse and Violence

Addiction and Violence:

Clinical Studies

*Psychological traits

*Psychiatric diagnosis

(addiction, depression anxiety, aggression)

D. Holschneider, J. Victoroff

USC Keck School of Medicine

Addiction: Social Studies

Using 10,000 methamphetamine abusers

*Demographics (gender, twins, ethnicity, type of substance, criminal justice status)

*Social factors (employment and environmental stressors)

*Developmental factors (childhood development, maternal smoking and substance use)

Y. Hser, UCLA

Neuro-imaging

A. Raine and others

USC College

of Letters, Arts and Sciences, Psychology

Bioinformatics

D. Conti

USC Keck School of Medicine

Animal Models (transgenic mice)

Metabolome (correlate brain and urine levels)

Behavior

K. Chen, USC School of Pharmacy

D. Holschneider, USC Keck School of Medicine

DNA, SNP Mutation Discovery

(Genes in serotonin and dopamine pathways)

J. Shih, K. Chen, USC School of Pharmacy

D. Conti, USC Keck School of Medicine

L. Baker,USC College of Letters, Arts & Sciences,

Psychology

Education

J. Colbert, M. Sundt, USC School of Education

R. Aster, USC School of Social Worker