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ANTICANCER AND ANTI-HIV DRUGS DERIVED FROM AFRICAN AND OTHER PLANTS Gordon Cragg, Ph.D. NIH Special Volunteer Natural Products Branch Developmental Therapeutics Program Division of Cancer Treatment and Diagnosis
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AFRICAN AND OTHER PLANTS
Gordon Cragg, Ph.D.
NIH Special Volunteer
Natural Products Branch
Developmental Therapeutics Program
Division of Cancer Treatment and
Fairview Center, Suite 206
P. O. Box B
Frederick, MD 21702-1201, U. S. A.
Phone: 301-846-5387; fax: 301-846-6178
website: http://dtp.nci.nih.gov; http://dtp.nci.nih.gov/branches/npb/index.html
*Farnsworth NR, et al. Medicinal Plants in Therapy. Bull. W.H.O. 63:965-981 (1985)
Epothilone A docked in tubulin active site
Isolated from gliding
Nettles et al., "The Binding Mode of Epothilone A on a,ß-Tubulin by Electron Crystallography"
Science, 6 August 2004, Vol. 305, pp. 866-869 (Copyright AAAS)
IN CLINICAL USE OR DEVELOPMENT
Dr. D. Soejarto
U. Illinois at Chicago
- Dried leaf analysis (N=>1,000): Up to 4% (w/w) MB.
expression in latently-
Calophyllum teysmannii var. inophylloide. Sustainable source of potential anti-AIDS
drug, calanolide B. Discovery from tree in Sarawak, Malaysia, promoted conservation and replanting of seedlings in clearcut regions, and led to establishment of the
Sarawak Biodiversity Center for in-country
research on drug discovery from local biodiversity
D.D. Soejarto, University of Illinois at Chicago
1996: Joint venture company, Sarawak Medichem
AND THE DISCOVERY OF
NOVEL CONVENTIONAL DRUGS
Any herbal drug or botanical supplement to be considered for clinical trials must be botanically authenticated as well as chemically and biologically standardized.
Dr. Norman Farnsworth, Director, UIC/NIH Center for Botanical Dietary
Steps Required Prior to Clinical Assessment of Herbal Drugs/Botanical Dietary Supplements
Thank you for visiting this website, which is intended to be a network hub for all
stakeholders in Africa’s natural plant products sector. Through knowledge-sharing
and information-exchange via this site, ASNAPP (Agribusiness in Sustainable
Natural African Plant Products) seeks to create a knowledge community that will
strengthen the continent’s capacity to develop this sector.
In the interests of developing successful natural product agribusinesses, and thus
helping to reduce poverty in rural communities, ASNAPP promotes collaboration
and knowledge sharing with research and academic institutions, government,
private enterprises, non-profit organizations, the donor community and civil
For this purpose, the ASNAPP website encourages information exchange in any of the
Applied research and technology transfer
Quality assurance and control
Market linkages and development
Enterprise and farmer association development
Natural resource management
Policy dialogue and advocacy
These areas are the main thrust of ASNAPP’s activities for 2005, based on the following
three new programmes funded by the United States Agency for International Development (USAID):
The Partnership for Food Industry Development Program (PFID), managed by
Rutgers University’s New Use Agriculture and Natural Plants Products Program.
The Rural Livelihoods Activity in Southern Africa programme, run by the Michigan
State University Partnership for Food Industry Develop Program – Fruits and
Vegetables (MSU PFID – F & V) in conjunction with a consortium of partners.
The Partnership for Sustainable Germplasm Development for Non-traditional
Crops, a collaborative project involving various academic and research institutions
as well as private enterprises in South Africa and Zambia.
ASNAPP USARutgers University - Cook CollegeDepartment of Plant Biology and Plant Pathology59 Dudley Road, 381 Foran HallNew Brunswick, New Jersey 08901Professor Jim SimonCo-Principal Investigator and Quality Control Coordinator ASNAPP ProgramNew Use Agriculture and Natural Plants ProgramTel: +732 932-9711 Ext. 355/379Fax: +732 932-9377Email: email@example.comWebsite: www.nuanpp.org
Partner countries: Ghana, Rwanda, Senegal, South Africa, Zambia, USA
and Alternative Medicine (CAM)
While many CAM treatments have already been in use for
a long time (sometimes for centuries), there is not the kind
of scientific knowledge available about them that has been
gained from studies of conventional medicine. Many people
are already using CAM, and without this scientific knowledge,
they may be at risk— for example, for serious effects from
taking the wrong dose, using the treatment in the wrong way,
or using it with another treatment with which it interacts.
ADDIS ABABA 2003
August 9-12, 2005