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Acknowledgment. Rupp SM, Castagnoli KP, Fisher DM, Pancuronium and vecuronium pharmacokinetics and pharmacodynamics in younger and elderly adults. Anesthesiology 1987 67:45-9.. Case 1. 60 kg, 50 year old cachectic woman with large pelvic massInduced with 5 mg vecuroniumAt 60 minutes, twitch = 1 out of 4, and the surgeon reports the abdominal wall is tight.In response, an additional 5 mg of vecuronium was given.Case ends at 90 minutes, patient can\'t be extubated until about 150 minutes.

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