Chapter 3 Antigens. Substances which can be recognized by Ig of B cells (at F ab sites) and TCR’s of T cells (when accompanied by MHC) B and T cells also differ in the way they recognize Ag. Complementarity of Ag binding (Ab on left; Ag on right). Terminology:.
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Complementarity of Ag binding (Ab on left; Ag on right)
B cell response
*Development of both Humoral and Cell-mediated IR requires T cell recognition of processed/ presented Ag
*large, insoluble macromolecules and polymers are better immunogens than small and soluble
*those molecules resistant to enzyme degradation (esp. D-amino acids) are poor immunogens
-there is a strong genetic link to immune response
-e.g., MHC gene products, genes encoding B/T receptors
2)Dosage and route of Ag admin – exp’tl evidence indicates a dose-response curve to every immunogen
-insufficient doses nonresponse or tolerance
-single doses insignificant response (excessive too!)
-“booster” shots are required for many immunizations
-route affects which immune organ/cells involved…
how this works is not entirely understood, but they appear to help by: