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Will Avian Influenza become Human? Question : How could H5N1 become dangerous to humans? Mutation of H5 to bind to human receptors? Re-assortment by genetic shift to H1N1? Biology of Influenza A H5N1 and H1N1 ClustalW separates man from bird. http://workbench.sdsc.edu

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slide1

Will Avian Influenza become Human?

  • Question: How could H5N1 become dangerous to humans?
    • Mutation of H5 to bind to human receptors?
    • Re-assortment by genetic shift to H1N1?

Biology of Influenza A

H5N1 and H1N1 ClustalW separates man from bird.

http://workbench.sdsc.edu

http://www.vetscite.org/publish/articles/000041/img0002.jpg

From PDB Molecule of the Month

  • H (16 types)N (9types) designation
    • H types that infect humans 1, 2, 3
    • H types that infect birds: 3, 4, 6 (freq) 5,7 less common
  • Bird Flu=H5N1

http://www.ebi.ac.uk/interpro/potm/2006_4/Page1.htm

Ab covering HA

Genetic shift vs. drift

A/Thailand/1[KAN-1A]/2004[H CPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDA

A/Vietnam/PEV16T/2005[H5N1] CPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVMWGIHHPNDA

A/chicken/Thailand/Kanchana CPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDA

A/chicken/Thailand/Nontabur CPYQGKSSFFRNVVWLIKKNSTYPIIKRSYNNTNQEDLLVLWGIHHPNDA

A/quail/Thailand/Nakhon_Pat CPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDA

A/goldeneye_duck/Bavaria/19/ CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA

A/tufted_duck/Bavaria/9/2006 CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA

A/swan/Bavaria/16/2006[H5N1] CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA

A/swan/Bavaria/6/2006[H5N1] CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA

A/buzzard/Bavaria/5/2006[H5N CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA

A/tufted_duck/Bavaria/8/2006 CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA

A/swan/Bavaria/17/2006[H5N1] CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA

A/swan/Bavaria/21/2006[H5N1 CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA

A/teal/Egypt/14051-NAMRU3/2 CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA

A/goosander/Switzerland/V82/ CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA

A/chicken/Egypt/10845-NAMRU CPYQGRSSFFRNVVWLIKKDNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA

A/goose/Guangzhou/471/2006[ CPYQGTPSFFRNVVWLIKKNNTYPTIKRSYNNTNQEDLLILWGIHHSNDA

A/China/GD01/2006[H5N1] CPYQGTPSFFRNVVWLIKKNNTYPTIKRSYNNTNQEDLLILWGIHHSNNA

A/Owston's_civet/Vietnam/1/2 CPYQGNSSFFRNVVWLIKKNDAYPTIKRSYNNTNQEDLLVLWGIHHPNDE

A/Indonesia/CDC887/2006[H5N CPYLRSPSFFRNVVWLIKKNSTYPTIKKSYNNTNQEDLLVLWGIHHPNNE

A/Indonesia/CDC836T/2006[H5 CPYLGSPSFFRNVVWLIKKNSTYPTIKKSYNNTNQEDLLVLWGIHHPNDA

A/teal/Egypt/9885-NAMRU3/20 CPYNGRSSFFRNVVWLIKKNNAYPTIKRSYNNTNQEDLLVLWGIHHPNDA

*** .************:.:** **:***********::*****.*:

A/Thailand/1[KAN-1A]/2004[H AEQTKLYQNPTTYISVGTSTLNQRLVPRIATRSEVNGQSGRMEFFWTILK

A/Vietnam/PEV16T/2005[H5N1] AEQTKLYQNPTTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILK

A/chicken/Thailand/Kanchana AEQTKLYQNPTTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILK

A/chicken/Thailand/Nontabur AEQTKLYQNPTTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILK

A/quail/Thailand/Nakhon_Pat AEQTKLYQNPTTYISVGTSTLNQRLVPRIATRPKVNGQSGRMEFFWTILK

A/goldeneye_duck/Bavaria/19/ AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK

A/tufted_duck/Bavaria/9/2006 AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK

A/swan/Bavaria/16/2006[H5N1] AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK

A/swan/Bavaria/6/2006[H5N1] AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK

A/buzzard/Bavaria/5/2006[H5N AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK

A/tufted_duck/Bavaria/8/2006 AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK

A/swan/Bavaria/17/2006[H5N1] AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK

A/swan/Bavaria/21/2006[H5N1 AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK

A/teal/Egypt/14051-NAMRU3/2 AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK

A/goosander/Switzerland/V82/ AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK

A/chicken/Egypt/10845-NAMRU AEQTRLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK

A/goose/Guangzhou/471/2006[ AEQTKLYQNPTTYISVGTSTLNQRLVPKIATRSKVNGQSGRMDFFWTILK

A/China/GD01/2006[H5N1] AEQTKLYQNPTTYISVGTSTLNLRLVPKIATRSKVNGQSGRMDFFWTILK

A/Owston's_civet/Vietnam/1/2 AEQTRLYQNPTTYVSIGTSTLNQRLVPKIATRSKVNGQSGRIDFFWTILK

A/Indonesia/CDC887/2006[H5N AEQTRLYQNPTTYISIGTSTLNQRLVPKIATRSKVNGQSGRMEFFWTILK

A/Indonesia/CDC836T/2006[H5 AEQTRLYQNPTTYISIGTSTLNQRLVPKIATRSKVNGQSGRMEFFWAILK

A/teal/Egypt/9885-NAMRU3/20 AEQTKLYQNPTTYVSVGTSLLNQRSVPEIATRPKVNGQSGRMEFFWTILK

****:********:*:*** ** * **.****.:*******::***:***