insulin signalling. Neuro - anatomy of homeostatic regulation of food intake ; opposing actions of AgRP /NPY and POMC/CART containing neurons.
Increased concentration of glucose in the blood, after a meal, leads to increased ATP production in the pancreatic b-cell and this in turnreduces K+ outflow, leading to membrane depolarisation. The subsequent C2+ entry constitutes the secretion signal
(or PTB domain)
from IRS1 (or insulin receptor)
PDK2 : phosphatidyl inositol-dependent protein kinase 2 was so named because the identity was unclear. It is now generally agreed that the mTOR/Rictor complex provides the initial phosphorylation
A lack of glucose blocks the mTOR-mediatedanorectic signal. This occursthrough an increase of 5’-AMP whichisproduced in a « rescue » pathwaywheretwo ADP are combined to raise the level of ATP