insulin signalling n.
Skip this Video
Loading SlideShow in 5 Seconds..
insulin signalling PowerPoint Presentation
Download Presentation
insulin signalling

Loading in 2 Seconds...

play fullscreen
1 / 21

insulin signalling - PowerPoint PPT Presentation

  • Uploaded on

insulin signalling. Neuro - anatomy of homeostatic regulation of food intake ; opposing actions of AgRP /NPY and POMC/CART containing neurons.

I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
Download Presentation

PowerPoint Slideshow about 'insulin signalling' - oshin

An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.

- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
Neuro-anatomy of homeostaticregulation of foodintake; opposing actions of AgRP/NPY and POMC/CART containingneurons

Increased concentration of glucose in the blood, after a meal, leads to increased ATP production in the pancreatic b-cell and this in turnreduces K+ outflow, leading to membrane depolarisation. The subsequent C2+ entry constitutes the secretion signal

Release of insulin in response to glucose leads to glucose uptake and storage in the form of glycogen (in muscle and liver)
recruitment of adaptors and effectors through domains that bind phosphotyrosine containing peptides
Recruitment of adaptors and effectorsthroughdomainsthatbindphosphotyrosine-containing peptides

SH2 domain

(or PTB domain)

phosphotyrosine peptide

from IRS1 (or insulin receptor)


A downstreameffector of PI 3-kinase is the protein kinase PKB

PDK2 : phosphatidyl inositol-dependent protein kinase 2 was so named because the identity was unclear. It is now generally agreed that the mTOR/Rictor complex provides the initial phosphorylation

PKB stimulates the mTORpathway, whichalsoprovides a anorectic signal (via an as yetunclearpathway)

A lack of glucose blocks the mTOR-mediatedanorectic signal. This occursthrough an increase of 5’-AMP whichisproduced in a « rescue » pathwaywheretwo ADP are combined to raise the level of ATP

The global picture of insulin, leptin, glucose and amino-acid –mediatedregulation of foodintake via mTOR and AMPK