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Equine Infectious Anemia. Andrea Jensen & Emily French. Discovery History . Horsey AIDS?… NOT. Lentiviruses. Retrovirus Family Single Strand (+) RNA virus Contains 2 copies Can infect non-dividing cells Contains regulatory proteins Latent or active viral states

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equine infectious anemia

Equine Infectious Anemia

Andrea Jensen

&

Emily French

lentiviruses
Lentiviruses
  • Retrovirus Family
  • Single Strand (+) RNA virus
  • Contains 2 copies
  • Can infect non-dividing cells
  • Contains regulatory proteins
  • Latent or active viral states
  • Spread by blood and other bodily fluids
  • Long lived virus leading to reservoir for persistent infection
  • Virus type present in many vertebrate species
the next 30 minutes of your life
The next 30 minutes of your life…
  • Transmission
  • Pathology
  • Testing and Control
  • Vaccine research, EIAV/FIV
  • What does it mean to Me?
transmission
Transmission
  • Vicki 15 min of fame
primary pathology
Primary Pathology
  • Mature RBC’s destroyed by immune system
  • Maturation of RBC precursor cells prevented
other eiav symptoms
Other EIAV Symptoms
  • Depression
  • Fever
  • Enlarged Lymph Nodes
  • Weakness
  • Weight Loss
  • Anorexia
  • Edema
  • Nasal Discharge
  • DEATH
how eiav stacks up
How EIAV Stacks Up
  • HIV “generally” fatal
  • FIV is “Kitty AIDS”
  • EIAV has 30% mortality
so now you know
So now you know…..

What EIAV is and what it means for the horse.

But what are we doing about it?

  • Mandatory Testing
  • Federally Mandated Control Measures
  • Vaccine Research
current testing
Current Testing
  • Agar gel immunodiffusion test (AGID or Coggin’s)
  • Competitive enzyme-linked immunosorbant assay (cELISA)

AGID / Coggin’s

cELISA

control measures
Control Measures
  • Life-long quarantine
  • Slaughter
  • Research
  • Euthanasia
what this means is
What this means is…

70% of horses that contract EIAV would

effectively manage the infection….

But…..

100% of horses who have a positive Coggin’s Test

will die as a result of the test.

vaccines
Vaccines

No.

Yes.

Well, Maybe…

why do we even care
Why do we even care?
  • Vaccine Research
  • Therapeutic Vectors
  • Immune System