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By: Kim Mendez The first picture taken of Ebola 1976, under a scanning electron micrograph Classified as Filoviridae There are four strains of Ebola: Ebola Sudan, Ebola Zaire, Ebola Reston, Ebola Tai (Ivory Coast) How Ebola is Contracted: Signs and symptoms:

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Presentation Transcript
slide2
The first picture taken of Ebola
  • 1976, under a scanning electron micrograph
  • Classified as Filoviridae
  • There are four strains of Ebola: Ebola Sudan, Ebola Zaire, Ebola Reston, Ebola Tai (Ivory Coast)
signs and symptoms
Signs and symptoms:
  • Early symptoms: Malaise fatigue, fever, low back ache, N, V, D
  • Late symptoms: Conjunctivitis, hemorrhagic rash, genital edema, bleeding from E, E, N, T…then DEATH
species jump
Species Jump:

It can jump from monkey to human by the consumption of “bush meat”

filoviridae on cell surface
Filoviridae on cell surface

Elongated and narrow appearance (unlike most viruses which are bumpy and round)

first recorded outbreak of ebola
First Recorded Outbreak of Ebola
  • A small village (Yambuku) in Northern Zaire, Africa
areas of recent outbreaks zaire sudan gabon nigeria liberia cameroon ivory coast and kenya
Areas of recent outbreaks, Zaire, Sudan, Gabon, Nigeria, Liberia, Cameroon, Ivory Coast, and Kenya

Legend: Villages in the countries

1995 outbreak
1995 Outbreak!!
  • Alice, TX– 2 Cynomolgus monkeys imported from the Philippines are discovered to contain the deadly virus.
ribavirin
Ribavirin

Treatment...antiviral drug, supportive therapy, and rehydration

slide15

C

Y

A

N

O

V

I

R

I

N

Crystal Structure

Extracted from blue-green algae

slide16
cDNA
  • Reverse genetics.. isolating RNA from Ebola
lab accidents
Lab Accidents
  • Most recent lab accident was in Russia (May 2004)
references
References:
  • Health.allrefer.com
  • Barrientos LG, O’Keefe BR, Bray M, Sanchez A, Gronenborn AM, Boyd MR. (2003) Cyanovirin-N binds to the viral surface glycoprotein GP 1,2 and inhibits infectivity of Ebola virus. Antiviral Research 2003.
  • Center for Disease Control. (2002) Ebola Hemorrhagic Fever. http://www.mindspring.com/~cinque/ebola.html
  • Scanning electron micrograph of Ebola virus-infected cell showing numerous virions (arrow) on the cell surface. C.S. Goldsmith and J. Carr. From A. Sanchez, A.S. Kahn, S.R. Zaki, G.J. Nabel, T.G. Ksiazek, C.J. Peters, in Fields VIROLOGY, Fourth Edition, 2001
  • http://www.bio.davidson.edu/Courses/Immunology/Students/Spring2003/Austin/Immune-2.html
  • http://www.vetmed.wisc.edu/pbs/kawaoka/research.html
  • http://images.google.com/imgres?imgurl=http://www.ccds.charlotte.nc.us/History/images/ebopsterjpg.jpg&imgrefurl=http://www.ccds.charlotte.nc.us/History/Africa/04/burton/burton.htm&h=225&w=150&sz=10&tbnid=9txwBGWfTycJ:&tbnh=102&tbnw=68&start=174&prev=/images%3Fq%3DEbola%2BVirus%26start%3D160%26hl%3Den%26lr%3D%26ie%3DUTF-8%26sa%3DN